Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
H5388
Hyaluronic acid sodium salt from rooster comb
avian glycosaminoglycan polysaccharide
Synonym(s):
Poly(β-glucuronic acid-[1→3]-β-N-acetylglucosamine-[1→4]), alternating
About This Item
Recommended Products
biological source
chicken (rooster comb)
Quality Level
form
powder
impurities
≤2% protein (Lowry)
color
white
solubility
water: ~5 g/L
cation traces
Na: 3-7%
storage temp.
−20°C
SMILES string
[Na+].N([C@H]1[C@@H](O[C@@H]([C@H]([C@@H]1O[C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)C(=O)O)O)CO)O[C@@H]2[C@H](O[C@H]([C@@H]([C@H]2O)O)O[C@@H]3[C@H]([C@@H](O[C@@H]([C@H]3O)CO)O)NC(=O)C)C(=O)O)C(=O)C
InChI
1S/C28H44N2O23.Na/c1-5(33)29-9-18(11(35)7(3-31)47-25(9)46)49-28-17(41)15(39)20(22(53-28)24(44)45)51-26-10(30-6(2)34)19(12(36)8(4-32)48-26)50-27-16(40)13(37)14(38)21(52-27)23(42)43;/h7-22,25-28,31-32,35-41,46H,3-4H2,1-2H3,(H,29,33)(H,30,34)(H,42,43)(H,44,45);/q;+1/t7-,8-,9-,10-,11-,12-,13+,14+,15-,16-,17-,18-,19-,20+,21+,22+,25-,26+,27-,28-;/m1./s1
InChI key
YWIVKILSMZOHHF-QJZPQSOGSA-N
Application
Biochem/physiol Actions
Other Notes
Storage Class Code
11 - Combustible Solids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
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Uncover more about glycosaminoglycans and proteoglycans including the structure of glycosaminoglycans (GAGs), the different types of GAGs, and their functions.
Uncover more about glycosaminoglycans and proteoglycans including the structure of glycosaminoglycans (GAGs), the different types of GAGs, and their functions.
Uncover more about glycosaminoglycans and proteoglycans including the structure of glycosaminoglycans (GAGs), the different types of GAGs, and their functions.
Protocols
To measure hyaluronidase activity, a turbidimetric determination assay is used at 600 nm. One unit of hyaluronidase activity will cause a change in absorbance of 0.330 per minute at pH 5.35 at 37 °C.
To measure hyaluronidase activity, a turbidimetric determination assay is used at 600 nm. One unit of hyaluronidase activity will cause a change in absorbance of 0.330 per minute at pH 5.35 at 37 °C.
To measure hyaluronidase activity, a turbidimetric determination assay is used at 600 nm. One unit of hyaluronidase activity will cause a change in absorbance of 0.330 per minute at pH 5.35 at 37 °C.
To measure hyaluronidase activity, a turbidimetric determination assay is used at 600 nm. One unit of hyaluronidase activity will cause a change in absorbance of 0.330 per minute at pH 5.35 at 37 °C.
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How is shipping temperature determined? And how is it related to the product storage temperature?
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How can I determine the shelf life / expiration / retest date of this product?
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If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdfHelpful?
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Mol Wt of H5388 (CAS Number 9067-32-7) Please share the Sodium Hyaluronate (g quantity) I am looking for Mol.Wt 100-200 Kda
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This product has not been tested to determine the molecular weight. However, historical information indicates a range of 1.6 - 2 MDa. Currently, there is no product available at a molecular weight of 100-200 kDa. Product H7630, from bovine vitreous humor, has historically demonstrated a molecular weight of approximately 300 kDa. Please see the link below to review this product:
https://www.sigmaaldrich.com/product/sigma/h7630Helpful?
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What is the Department of Transportation shipping information for this product?
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Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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What is the purity of Hyaluronic acid, Product H5388?
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Sigma does not perform purity testing on this product due to the variable molecular weight and degradation that may occur in native glycosaminoglycans. This product is tested for activity and protein content which provide information regarding impurities and suitability.
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What is the molecular weight of Hyaluronic acid, Product H5388?
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Product No. H5388 is a linear heteropolysaccharide with repeating 3-O-(β-D-glucuronido)-N-acetyl-D-glucosamine units linked by β-(1-->4)) hexosaminidic bonds. The molecular weight of this subunit has not been determined, but could be calculated from the information above. Molecular weights of hyaluronic acids vary from 0.1-10 million, depending on the source. The hyaluronic acid from rooster comb is expected to have a molecular weight of 1-4 million.
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What is the solubility of Hyaluronic acid, Product H5388?
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For Sigma's analytical test, 15 mg of this product is dissolved in 5 mL of 0.3 M phosphate buffer, pH 5.35 at 25°C (i.e., 3 mg/mL).
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