Skip to Content
Merck
All Photos(3)

Documents

E7138

Sigma-Aldrich

Ethosuximide

Synonym(s):

2-Ethyl-2-methylsuccinimide

Sign Into View Organizational & Contract Pricing
All Photos(3)

About This Item

Empirical Formula (Hill Notation):
C7H11NO2
CAS Number:
77-67-8
Molecular Weight:
141.17
EC Number:
201-048-7
MDL number:
MFCD00072123
UNSPSC Code:
12352111
PubChem Substance ID:
24278423
NACRES:
NA.77

solubility

ethanol: 100 mg/mL

SMILES string

O=C1NC(CC1(C)CC)=O

InChI

1S/C7H11NO2/c1-3-7(2)4-5(9)8-6(7)10/h3-4H2,1-2H3,(H,8,9,10)

InChI key

HAPOVYFOVVWLRS-UHFFFAOYSA-N

Gene Information

human ... CACNA1G(8913) , CACNA1H(8912) , CACNA1I(8911)

Looking for similar products? Visit Product Comparison Guide

Application

Ethosuximide has been used:
  • to confirm its effect on spike wave discharges (SWD) in rats
  • to examine its effects on spontaneous locomotion and anxiety-related thigmotaxis behaviours in zebrafish larvae of wild type
  • as a model drug for the treatment of epilepsy in vivo(4)

Biochem/physiol Actions

Ethosuximide is an anticonvulsant drug and an antagonist for T-type calcium channel. It is known to prevent spike wave discharges, characterized in absence seizures.

Features and Benefits

This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Self-assembling PVA-F127 thermosensitive nanocarriers with highly sensitive magnetically-triggered drug release for epilepsy therapy in vivo
Huang HY, et al.
Journal of Materials Chemistry, 22(17), 8566-8573 (2012)
Behavioural responses of zebrafish larvae to acute ethosuximide exposure
Ji Y, et al.
Behavioural Pharmacology, 28(6), 428-440 (2017)
N Leresche et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 18(13), 4842-4853 (1998-06-23)
The action of ethosuximide (ETX) on Na+, K+, and Ca2+ currents and on tonic and burst-firing patterns was investigated in rat and cat thalamic neurons in vitro by using patch and sharp microelectrode recordings. In thalamocortical (TC) neurons of the
Gabi Dezsi et al.
Epilepsia, 54(4), 635-643 (2013-03-08)
Ethosuximide (ESX) is a drug of choice for the symptomatic treatment of absence seizures. Chronic treatment with ESX has been reported to have disease-modifying antiepileptogenic activity in the WAG/Rij rat model of genetic generalized epilepsy (GGE) with absence seizures. Here
Emilio Russo et al.
Epilepsia, 52(7), 1341-1350 (2011-06-04)
Depression is most commonly associated with epilepsy. Recent reports have suggested a putative relationship between seizure development and onset of depressive behavior, whereas others proposed that two clinical entities might represent different neuropathologic aspects of the same neurologic disorder. The
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service