Creatine Kinase is a dimer that exists as three isozymes: MM (muscle), MB (hybrid) and BB (brain).
C9858
Creatine Kinase MM Fraction from human heart
lyophilized powder
Synonym(s):
CK-MM Fraction, Human CK MM, Human Creatine Kinase
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Specificity
One unit will transfer 1.0 μmole of phosphate from creatine phosphate to ADP per minute at 37 °C (measured at 340 nm as one equimolar amount of NADH produced by coupled reaction).
Application
Creatine kinase MM fraction from human heart has been used in a study to investigate the importance of intraoperative and postoperative cardiac medical therapy in emergency coronary artery bypass grafting for acute myocardial infarction. Creatine kinase MM fraction from human heart has also been used in a study to investigate the circadian dependence of infarct size and left ventricular function after ST slevation myocardial infarction.
Biochem/physiol Actions
May be used as a control or calibrator in monitoring myocardial injury.
Warning
All human source materials have tested negative for HIV1, HIV2, HCV antibodies and HbsAg. No test guarantees a product to be non-infectious. Therefore, all material derived from human fluids or tissues should be considered as potentially infectious.
Unit Definition
One unit will transfer one micromole of phosphate from creatine phosphate to ADP per minute at 37 deg C.
Physical form
Lyophilized powder containing Tris-HCl, EDTA and N-acetyl cysteine.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Journal of the American College of Cardiology, 59(8), 730-738 (2012-02-22)
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