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A6655

Sigma-Aldrich

Aflatoxin B₁−BSA Conjugate

from Aspergillus flavus, powder, hepatotoxic mycotoxin

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About This Item

MDL number:
UNSPSC Code:
12352202
NACRES:
NA.77

product name

Aflatoxin B1−BSA Conjugate from Aspergillus flavus,

form

powder

Quality Level

extent of labeling

8-12 mol Aflatoxin B1 per mol BSA

storage temp.

2-8°C

General description

Aflatoxin B1 is the most toxic aflatoxin. Aflatoxins are hepatotoxic metabolites, that are produced by molds, such as Aspergillus flavus and Aspergillus parasiticus. Aflatoxins contaminate human food and animal feed. They are linked to liver cancer, immune system suppression, reduced growth rates, losses in feed efficiency and death. They are naturally found toxic carcinogens and the most widely known mycotoxins. They mainly contaminate fruits, vegetables and grains.

Application

Aflatoxin B1 is a carcinogenic compound that induces transversion of G to T at codon 249 of the p53 tumor suppressor gene.
Aflatoxin B1-BSA Conjugate from Aspergillus flavus has been used in immunization of mice with phage and synthetic peptide. It is also used as a target molecule in si field-effect transistor (FET) biosensing techniques.

Warning

Possibly carcinogenic.

Pictograms

Skull and crossbonesHealth hazard

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral - Carc. 1B

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Morvarid Karamkhani et al.
Environmental monitoring and assessment, 192(7), 472-472 (2020-07-02)
Many workers are exposed to health problems arising from molds, fungi, and their toxins during waste processing. Aflatoxin B1 (AFB1) level in airborne and settled dust, aflatoxin B1-albumin (AFB1-Alb) adduct in serum, liver and kidney biochemical tests, and body redox
Detection of uncharged or feebly charged small molecules by field-effect transistor biosensors
Ah CS, et al.
Biosensors And Bioelectronics, 33(1), 233-240 (2012)
Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens (2008)
Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens (2008)
Regional differences in production of aflatoxin B1 and cyclopiazonic acid by soil isolates of Aspergillus flavus along a transect within the United States
Horn BW and Dorner JW
Applied and Environmental Microbiology, 65(4), 1444-1449 (1999)

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