75447
2-Oxoadipic acid
≥95.0% (HPLC)
Synonym(s):
α-Ketoadipic acid, 2-Oxoadipate, 2-Oxohexanedioic acid
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About This Item
Empirical Formula (Hill Notation):
C6H8O5
CAS Number:
Molecular Weight:
160.12
MDL number:
UNSPSC Code:
12352106
PubChem Substance ID:
NACRES:
NA.25
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Assay
≥95.0% (HPLC)
≥97.0% (T)
form
powder
lipid type
saturated FAs
storage temp.
2-8°C
SMILES string
OC(=O)CCCC(=O)C(O)=O
InChI
1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)
InChI key
FGSBNBBHOZHUBO-UHFFFAOYSA-N
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Related Categories
Application
- Engineering of phenylalanine dehydrogenase from Thermoactinomyces intermedius for the production of a novel homoglutamate: Showcases the application of 2-oxoadipic acid in enzyme engineering, enhancing biocatalytic processes for the production of novel compounds, vital for pharmaceutical and chemical industries (Tariq et al., 2022).
Biochem/physiol Actions
Important metabolite between the TCA cycle and lysine biosynthesis. Of interest for research on mitochondrial metabolite transporters.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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D G Hine et al.
Biomedical mass spectrometry, 11(7), 332-339 (1984-07-01)
Numerous abnormal metabolites were identified in large amounts in the urine of hypoglycin-treated rats using capillary gas chromatography/mass spectrometry-computer analysis. These metabolites are not detectable in significant amounts in normal rats' urine. Ten of them have not been previously associated
A patient with alpha-ketoadipic and alpha-aminoadipic aciduria.
M Duran et al.
Journal of inherited metabolic disease, 7(2), 61-61 (1984-01-01)
L Palmieri et al.
The Journal of biological chemistry, 276(3), 1916-1922 (2000-10-03)
The nuclear genome of Saccharomyces cerevisiae encodes 35 members of a family of membrane proteins. Known members transport substrates and products across the inner membranes of mitochondria. We have localized two hitherto unidentified family members, Odc1p and Odc2p, to the
Normal kynurenine metabolism in 2-oxoadipic aciduria.
A C Sewell et al.
Journal of inherited metabolic disease, 22(8), 949-950 (1999-12-22)
Iwona Gabriel et al.
FEMS yeast research, 13(2), 143-155 (2012-10-31)
The LYS12 gene from Candida albicans, coding for homoisocitrate dehydrogenase was cloned and expressed as a His-tagged protein in Escherichia coli. The purified gene product catalyzes the Mg(2+)- and K(+)-dependent oxidative decarboxylation of homoisocitrate to α-ketoadipate. The recombinant enzyme demonstrates
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