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Key Documents

P3750000

Propyphenazone

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

4-Isopropylantipyrine, 1,2-Dihydro-1,5-dimethyl-4-(1-methylethyl)-2-phenyl-3H-pyrazol-3-one, 1,2-Dihydro-4-isopropyl-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one, Isopropylphenazone, Propyphenazone

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About This Item

Empirical Formula (Hill Notation):
C14H18N2O
CAS Number:
Molecular Weight:
230.31
Beilstein:
204533
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

propyphenazone 

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

O=C1C(C(C)C)=C(C)N(C)N1C2=CC=CC=C2

InChI

1S/C14H18N2O/c1-10(2)13-11(3)15(4)16(14(13)17)12-8-6-5-7-9-12/h5-10H,1-4H3

InChI key

PXWLVJLKJGVOKE-UHFFFAOYSA-N

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Propyphenazone EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

related product

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Acute inferior myocardial infarction with low atrial rhythm due to propyphenazone: Kounis syndrome.
Ahmet Akyel et al.
International journal of cardiology, 148(3), 352-353 (2010-06-15)
Rosario Rodil et al.
Water research, 46(7), 2457-2468 (2012-03-03)
Chlorination is one of the most popular disinfection steps for water treatment in Europe. However, chlorine can react with pharmaceuticals and other micropollutants leading to either their elimination or by-products being formed. These by-products are frequently not identified and therefore
Deniz Emre et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 847(2), 126-132 (2006-10-19)
A new micellar electrokinetic capillary chromatographic method has been developed to analyze the pharmaceutical preparations containing ternary combination of paracetamol (PAR), caffeine (CAF) and propyphenazone (PRO). Best results were obtained by using 20mM pH 9.0 borate buffer containing 30mM sodiumdodecylsulphate
Sebastian Zühlke et al.
Journal of chromatography. A, 1050(2), 201-209 (2004-10-29)
A new analytical method applying in situ derivatization was developed to enable the extraction of polar drug metabolites from water samples by solid-phase extraction (SPE). An additional derivatization by silylation was used to enhance the sensitivity of analyte detection by
Ngoc Han Tran et al.
Journal of hazardous materials, 171(1-3), 1051-1057 (2009-07-21)
The biodegradation of 10 selected pharmaceuticals by enriched nitrifier cultures with ammonia oxidizing activity of 30mg NH(4)-N/gMLVSSh was investigated under various initial operating conditions such as in the presence of different growth substrates and inhibitors. The enriched nitrifier culture showed

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