The solubility of gonadorelin (acetate) in ethanol is roughly 0.25 mg/ml and about 30 mg/ml in DMSO and DMF.
869003-M
Luteinizing Hormone, Human Pituitary, Iodination Grade
Synonym(s):
Luteinizing Hormone, Human Pituitary, Iodination Grade, hLH
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About This Item
form:
solid
Assay:
≥95% (weight)
Pricing and availability is not currently available.
Recommended Products
Assay
≥95% (weight)
Quality Level
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
impurities
≤0.05% hCG
≤0.5% hFSH, hTSH
color
white
solubility
water: 1 mg/mL
storage temp.
−20°C
General description
Native, human luteinizing hormone from pituitary gland. A heterodimeric glycoprotein hormone required for ovulation, spermatogenesis, and the biosynthesis of sex steroids. Biological specificity has been attributed to the β-chain. Potency: ≥5000 IU/mg
Native, human luteinizing hormone from pituitary gland. Heterodimeric glycoprotein hormone secreted by the anterior pituitary gland that is required for ovulation, spermatogenesis, and the biosynthesis of sex steroids. Regulates biosynthesis and/or secretion of sex steroids. In the female, LH stimulates synthesis of progesterone in the ovaries, release of estrogen from Graafian follicles, induction of ovulation, and formation of the corpus luteum. In the male, LH stimulates testosterone secretion by the testes. Biological specificity has been attributed to the β-chain.
Biochem/physiol Actions
≥ 5,000 IU/mg
Warning
Toxicity: Carcinogenic / Teratogenic (D)
Other Notes
Ramanujam, L.N., et al. 1999. Clin. Endocrinol.51, 243.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Could you please provide instructions on how to reconstitute product number 869003, specifically Luteinizing Hormone, Human Pituitary, Iodination Grade?
1 answer-
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Hello, Can this iodination grade hLH be used in rat LH radioimmunoassay or do you carry any iodination grade rLH?
1 answer-
The suitability of this product in rat studies has not been determined. It has been shown that iodination may lower the potency of LH and a lower affinity to hormonal receptors. It may be helpful to view a similar product L6420. Again, this product has not been tested for suitability in rat.
Below are some references that may be helpful in determining if these products would be suitable for the specified application.1. Effect of Iodination on the Biological Activity and Metabolism of Human Luteinizing Hormone
https://academic.oup.com/jcem/article-abstract/28/5/613/27156322. Iodination of Luteinizing Hormone-Releasing Hormone
https://pubs.acs.org/doi/pdf/10.1021/bi00553a0063. Species specificity in the response of an in vitro amphibian (Xenopus laevis) ovulation assay to mammalian luteinizing hormones
https://www.sciencedirect.com/science/article/pii/0016648076900393Helpful?
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