345802

Gc-Globulin, Mixed Type, Human Plasma

Native Gc-globulin from human plasma. Single polypeptide chain present in plasma at about 20-55 mg/dl. Functions in binding and transport of vitamin D.

• Synonym(s): Gc-Globulin, Mixed Type, Human Plasma
• CAS Number: 68476-36-8
• UNSPSC Code: 12352202
• NACRES: NA.25

Properties

• biological source: human plasma
• Quality Level: 100
• Assay: ≥95% (SDS-PAGE)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• shipped in: ambient
• storage temp.: −20°C

Description

General description

Native Gc-globulin from human plasma. A single polypeptide chain present in plasma at a concentration of about 20-55 mg/100 ml. Functions in the binding and transport of vitamin D. May also play an important role in actin homeostasis; binds monomeric actin with high affinity. Binds membranes of both circulating B and T lymphocytes.

Native Gc-globulin from human plasma. Single polypeptide chain present in plasma at about 20-55 mg/dl. Functions in binding and transport of vitamin D.

Native Gc-globulin from human plasma. Single polypeptide chain present in plasma at about 20-55 mg/dl. Functions in binding and transport of vitamin D. May also play an important role in actin homeostasis as it has been shown to bind monomeric actin with high affinity. Binds to cell surface at the DBP binding site in a nonsaturable manner.

Application

Gc-Globulin, Mixed Type, Human Plasma, CAS 68476-36-8, is a single polypeptide chain that transports vitamin D. Binds to cell surface at the DBP binding site in a non-saturable manner.

Warning

Toxicity: Standard Handling (A)

Physical form

Lyophilized from 150 mM NaCl, 20 mM sodium phosphate buffer, pH 7.4.

Preparation Note

Prepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

Reconstitution

Following reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 1 year at -70°C.

Other Notes

Di Martino, S.J., and Kew, R.R. 1999. J. Immunol. 163, 2135.
Lee, W.M., et al. 1987. Hepatology7, 825.
Machii, T., et al. 1986. Acta Haematol.75, 26.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3