164598
Aminopeptidase M, Porcine Kidney
Synonym(s):
Aminopeptidase M, Porcine Kidney, Alanyl aminopeptidase, Aminopeptidase M, Aminopeptidase N
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About This Item
CAS Number:
MDL number:
UNSPSC Code:
12352202
NACRES:
NA.54
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biological source
Porcine kidney
Quality Level
form
suspension (crystalline)
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white
solubility
physiological buffer: soluble
water: soluble
foreign activity
Oxidases ≤3%
shipped in
ambient
storage temp.
2-8°C
Related Categories
General description
Aminopeptidase M (APM) is abundantly found in brush border membranes of the kidney, small intestine, placenta, and liver. It is a type II integral membrane protein, known as ectoenzyme.
Application
Aminopeptidase M, porcine kidney has been used:
- to test and identify the peaks containing d-residue in the allatotropin-related peptide (ATRP)
- to study its oxidative inactivation of enzyme activity, and to screen MIRA ingredients
- for the proteolysis of isolevuglandins (IsoLGs) proteins
Biochem/physiol Actions
Aminopeptidase M (APM) is implicated in terminating the actions of certain neuropeptides, like the enkephalins and angiotensin III in the brain. It also metabolizes specific vasoactive peptides. It functions as a receptor for certain viruses, such as coronavirus 229E. APM is a nonspecific peptidase, which rapidly breaks down l-residue peptides.
Packaging
Please refer to vial label for lot-specific concentration.
Warning
Toxicity: Harmful (C)
Unit Definition
One unit is defined as the amount of enzyme that will hydrolyze 1 µmol of Leu-pNA per min at 37°C, pH 7.2.
Physical form
Crystalline suspension in 3.2 M (NH₄)₂SO₄, 10 mM MgCl₂, 10 mM Tris-HCl, pH 7.5.
Other Notes
Wachsmuth, E.E., et al. 1966. Biochemistry5, 169.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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l- to d-residue isomerization is a post-translational modification (PTM) present in neuropeptides, peptide hormones, and peptide toxins from several animals. In most cases, the d-residue is critical for the biological function of the resulting d-amino acid-containing peptide (DAACP). Here, we
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