A homobifunctional, cleavable cross-linking reagent. Typically, reacted with primary amines in the pH range 7.0-10.0 to form amidine bonds.
Reactant for:
Synthesis of glutathione-sensitive cross-linked polyethylenimine gene vector
Preparation of cyclodextrin-containing polymers designed for gene delivery
Crosslinking of chick oviduct progesterone-receptor subunits
Caution
The reagant is readily hydrolyzed at neutral pH. Avoid use of reducing agents during coupling reactions.
Other Notes
Note that the amidine linkage preserves original primary amine positive charge. The disulfide linkage is cleavable by mild reduction. Incorporates an eight atom linker.
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Kanjiro Miyata (The University of Tokyo, Japan) provides insights on the rational design of polymeric materials for “smart” oligonucleotide delivery.
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