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385530

Sigma-Aldrich

N,N,N′,N′-Tetramethyl-O-(N-succinimidyl)uronium tetrafluoroborate

97%, for peptide synthesis

Synonym(s):

O-(N-Succinimidyl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate, TSTU

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About This Item

Empirical Formula (Hill Notation):
C9H16BF4N3O3
CAS Number:
105832-38-0
Molecular Weight:
301.05
MDL number:
MFCD00077875
UNSPSC Code:
12352107
PubChem Substance ID:
24864036
NACRES:
NA.22

product name

N,N,N′,N′-Tetramethyl-O-(N-succinimidyl)uronium tetrafluoroborate, 97%

Quality Level

300

Assay

97%

reaction suitability

reaction type: Coupling Reactions

mp

198-201 °C (lit.)

application(s)

peptide synthesis

functional group

amine
imide

storage temp.

2-8°C

SMILES string

F[B-](F)(F)F.CN(C)C(\ON1C(=O)CCC1=O)=[N+](\C)C

InChI

1S/C9H16N3O3.BF4/c1-10(2)9(11(3)4)15-12-7(13)5-6-8(12)14;2-1(3,4)5/h5-6H2,1-4H3;/q+1;-1

InChI key

YEBLHMRPZHNTEK-UHFFFAOYSA-N

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General description

N,N,N′,N′-Tetramethyl-O-(N-succinimidyl)uronium tetrafluoroborate is commonly used for the conversion of carboxylic acid into the corresponding N-hydroxysuccinimidyl (NHS) ester.

Application

N,N,N′,N′-Tetramethyl-O-(N-succinimidyl)uronium tetrafluoroborate may be used in the synthesis of N-succinimidyl 4-[18F]fluorobenzoate ([18F]SFB), a 18F-labeled agent used for labeling biomarkers. it may also be used for the activation of carboxylic group of C16-chained alkanethiols that are used in developing surface plasmon resonance (SPR) sensors.
Reactant for:
Linking sensor molecules with amino groups to amino functionalized AFM tips

Reactant for synthesis of:
A polymer supported oranotin reagent for prosthetic group labeling of biological macromolecules with radioiodine
L-Rhamnose antigen
Fluorinated rhodamines for optical microscopy and nanoscopy
c(RGDyK) targeted SN38 prodrug
Polyelectrolytes for thin film construction

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H317

Hazard Classifications

Skin Sens. 1A

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCBV2340
BCCG6615
BCCG7737
BCBW7170
BCBL9770V

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Facile synthesis of N?succinimidyl 4?[18F] fluorobenzoate ([18F] SFB) for protein labeling.
Tang G
Journal of Labelled Compounds & Radiopharmaceuticals, 51(1), 68-71 (2008)
A facile automated synthesis of N?succinimidyl 4?[18F] fluorobenzoate ([18F] SFB) for 18F?labeled cell?penetrating peptide as PET tracer.
Tang G
Journal of Labelled Compounds & Radiopharmaceuticals, 53(8), 543-547 (2010)
Compact and low-cost biosensor based on novel approach to spectroscopy of surface plasmons.
Piliarik M
Biosensors And Bioelectronics, 24(12), 3430-3435 (2009)
Red?emitting rhodamine dyes for fluorescence microscopy and nanoscopy.
Kolmakov K
Chemistry?A European Journal , 16(1), 158-166 (2010)
N-Succinimidyl 4-[18 F]-fluoromethylbenzoate-labeled dimeric RGD peptide for imaging tumor integrin expression.
Li W
Amino Acids, 43(3), 1349-1357 (2012)
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