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157260
1-Hydroxybenzotriazole hydrate
98% dry basis wetted with not less than 14 wt. % water, for peptide synthesis
Synonym(s):
HOBt Hydrate
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About This Item
Empirical Formula (Hill Notation):
C6H5N3O · xH2O
CAS Number:
Molecular Weight:
135.12 (anhydrous basis)
Beilstein:
4515
EC Number:
MDL number:
UNSPSC Code:
12352000
PubChem Substance ID:
NACRES:
NA.22
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Product Name
1-Hydroxybenzotriazole hydrate, wetted with not less than 14 wt. % water, 98% dry basis
Quality Level
Assay
98% dry basis
form
solid
quality
synthesis grade
reaction suitability
reaction type: Addition Reactions
mp
155-158 °C (lit.)
application(s)
peptide synthesis
SMILES string
[H]O[H].On1nnc2ccccc12
InChI
1S/C6H5N3O.H2O/c10-9-6-4-2-1-3-5(6)7-8-9;/h1-4,10H;1H2
InChI key
PJUPKRYGDFTMTM-UHFFFAOYSA-N
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General description
Application
1-Hydroxybenzotriazole hydrate can be used as a reagent:
- To synthesize β-peptides via microwave-assisted amino acid coupling.
- In the spot synthesis of glycopeptides.
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Product No.
Description
Pricing
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Aquatic Chronic 3 - Desen. Expl. 2 - Eye Irrit. 2
Supplementary Hazards
Storage Class Code
4.1A - Other explosive hazardous materials
WGK
WGK 1
Flash Point(F)
314.6 °F
Flash Point(C)
157 °C
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T Katoh et al.
International journal of peptide and protein research, 42(3), 264-269 (1993-09-01)
3-Dimethylphosphinothioyl-2(3H)-oxazolone (MPTO) was synthesized, and its ability to effect racemization-free couplings and cyclization of a peptide and its C-terminal epimer was examined. MPTO showed good reactivity in aprotic polar solvents such as N,N-dimethylformamide (DMF) and N-methylpyrrolidone. In reactivity MPTO resembles
Synlett, 733-733 (1993)
Tetrahedron Letters, 34, 6383-6383 (1993)
Tetrahedron Letters, 35, 3315-3315 (1994)
Akul Y Mehta et al.
Cell chemical biology, 27(9), 1207-1219 (2020-07-02)
Glycan recognition is typically studied using free glycans, but glycopeptide presentations represent more physiological conditions for glycoproteins. To facilitate studies of glycopeptide recognition, we developed Glyco-SPOT synthesis, which enables the parallel production of diverse glycopeptide libraries at microgram scales. The
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What is the Department of Transportation shipping information for this product?
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Why is Product 157260, Hydroxybenzotriazole hydrate wet?
1 answer-
Hydroxybenzotriazole hydrate is a solid that is explosive when dry. Our specification for this product is >14% water.
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Can Product 157260, Hydroxybenzotriazole hydrate, be dried?
1 answer-
Drying hydroxybenzotriazole hydrate should not be attempted because of its explosive nature.
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How is Product 157260, Hydroxybenzotriazole hydrate, shipped?
1 answer-
Hydroxybenzotriazole hydrate can not travel be sea or air. It is typically shipped by truck.
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