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130001

Sigma-Aldrich

1-Methylpiperazine

99%

Synonym(s):

N-Methylpiperazine

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About This Item

Empirical Formula (Hill Notation):
C5H12N2
CAS Number:
109-01-3
Molecular Weight:
100.16
Beilstein:
102724
EC Number:
203-639-5
MDL number:
MFCD00005966
UNSPSC Code:
12352100
PubChem Substance ID:
24847936
NACRES:
NA.22
Pricing and availability is not currently available.

vapor density

3.5 (vs air)

Quality Level

200

Assay

99%

form

liquid

refractive index

n20/D 1.466 (lit.)

bp

138 °C (lit.)

density

0.903 g/mL at 25 °C (lit.)

SMILES string

CN1CCNCC1

InChI

1S/C5H12N2/c1-7-4-2-6-3-5-7/h6H,2-5H2,1H3

InChI key

PVOAHINGSUIXLS-UHFFFAOYSA-N

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General description

1-Methylpiperazine is a heterocyclic diamine used as a versatile building block and intermediate in organic synthesis.[1][2][3]

Application

1-Methylpiperazine was used as mimic template in the preparation of molecularly imprinted microspheres (MIMs)[4]. It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative[5].

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Eye Dam. 1 - Flam. Liq. 3 - Skin Corr. 1B - Skin Sens. 1B

Storage Class Code

3 - Flammable liquids

WGK

WGK 1

Flash Point(F)

88.7 °F - closed cup

Flash Point(C)

31.5 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
STBK9370
STBH6027
STBF7104V
STBF1692V
STBD7150V

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Juxiang Ruan et al.
Journal of chromatography. A, 1297, 77-84 (2013-06-01)
This paper reports the preparation of a novel, silica-based, strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative. To prepare the difunctional strong anion-exchange stationary phase, activated silica beads were first bonded with 3-chloropropyltriethoxysilane and then reacted with 1-methylpiperazine followed by
Hongyuan Yan et al.
The Analyst, 137(12), 2884-2890 (2012-05-04)
A highly selective molecularly imprinted solid-phase extraction (MISPE) combined with liquid chromatography-ultraviolet detection was developed for the simultaneous isolation and determination of four plant hormones including indole-3-acetic acid (IAA), indole-3-propionic acid (IPA), indole-3-butyric acid (IBA) and 1-naphthaleneacetic acid (NAA) in
H Welinder et al.
International archives of allergy and applied immunology, 79(3), 259-262 (1986-01-01)
The presence of specific IgE antibodies against conjugates between human serum albumin and piperazine, a compound previously known to cause occupational asthma, and N-methyl-piperazine, respectively, was demonstrated by RAST, RAST inhibition and skin prick tests in 2 asthmatic subjects occupationally
E Gavathiotis et al.
Nucleic acids research, 28(3), 728-735 (2000-01-19)
The solution structure of the dodecamer duplex d(CTTTTGCAAAAG)(2)and its 2:1 complex with the bis -benzimidazole Hoechst 33258 has been investigated by NMR and NOE-restrained molecular dynamics (rMD) simulations. Drug molecules are bound in each of the two A-tracts with the
Andrius Žilionis
European journal of mass spectrometry (Chichester, England), 26(1), 25-35 (2019-08-21)
Liquid chromatography-tandem mass spectrometry is one of the most sensitive tools for determination of trace amounts of analytes in metabolomics and proteomics. The highest sensitivity is achieved in selected reaction monitoring detection, which involves fragmentation of the molecular ion between
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Questions

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  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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