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T5699

Sigma-Aldrich

m-3M3FBS

>97% (HPLC)

Synonym(s):

2,4,6-Trimethyl-N-(3-trifluoromethyl-phenyl)-benzenesulfonamide, N-(3-Trifluoromethylphenyl)-2,4,6-trimethylbenzenesulfonamide

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About This Item

Empirical Formula (Hill Notation):
C16H16F3NO2S
CAS Number:
200933-14-8
Molecular Weight:
343.36
MDL number:
MFCD00095824
UNSPSC Code:
41106300
PubChem Substance ID:
329826829
NACRES:
NA.77

Assay

>97% (HPLC)

form

powder

color

white

mp

114-114.8 °C (lit.)

solubility

DMSO: >20 mg/mL

SMILES string

Cc1cc(C)c(c(C)c1)S(=O)(=O)Nc2cccc(c2)C(F)(F)F

InChI

1S/C16H16F3NO2S/c1-10-7-11(2)15(12(3)8-10)23(21,22)20-14-6-4-5-13(9-14)16(17,18)19/h4-9,20H,1-3H3

InChI key

ZIIUUSVHCHPIQD-UHFFFAOYSA-N

Application

m-3M3FBS has been used for MAP kinase assay in 293T cells. It has also been used for intracellular calcium analysis1. Furthermore, it has been used (at a conc. of 1 μM) as a PLC activator for sensitizing TRPA1 in HEK293t cells2.

Biochem/physiol Actions

First known direct activator of phospholipase C (activates β2, β3, γ1, γ2, δ1 isoforms).

Preparation Note

m-3M3FBS is soluble in DMSO at a concentration that is greater than 20 mg/ml.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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