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SML2159

Sigma-Aldrich

Minodronic acid monohydrate

≥98% (HPLC)

Synonym(s):

[1-Hydroxy-2-(imidazo[1,2-a]pyridin-3-yl)ethylidene]bisphosphonic acid monohydrate

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About This Item

Empirical Formula (Hill Notation):
C9H12N2O7P2 · H2O
CAS Number:
155648-60-5
Molecular Weight:
340.16
MDL number:
MFCD20037380
UNSPSC Code:
12352106
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

0.1 M NaOH: 2 mg/mL, clear (warmed)

storage temp.

2-8°C

SMILES string

OC(P(O)(O)=O)(P(O)(O)=O)CC1=CN=C2N1C=CC=C2.O

InChI

1S/C9H12N2O7P2.H2O/c12-9(19(13,14)15,20(16,17)18)5-7-6-10-8-3-1-2-4-11(7)8;/h1-4,6,12H,5H2,(H2,13,14,15)(H2,16,17,18);1H2

InChI key

GPAPAOGRNKUFGH-UHFFFAOYSA-N

Biochem/physiol Actions

Bone resorption inhibitor; inhibitor of farnesyl diphosphate synthase
Minodronate is a third-generation bisphosphonate used clinically alone or in combination to treat osteoporosis. It is an inhibitor of farnesyl diphosphate synthase that acts as a bone resorption inhibitor.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000041079
0000041078
0000028196

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Shinichi Nakatoh
Journal of bone and mineral metabolism, 36(2), 221-228 (2017-03-16)
This study reveals the changes in bone mineral density (BMD), the turnover rate, and the balance [multiple of median formation/multiple of median resorption (MoMf/MoMr)] affected by the selection of different bone resorption inhibitors after 24-month daily teriparatide (20 µg/day) administration.
Motoaki Yasukawa et al.
Anticancer research, 36(11), 5883-5886 (2016-10-30)
Non-small cell lung carcinoma (NSCLC) is one of the leading causes of cancer-related death worldwide. Recent studies showed that nitrogen-containing bisphosphonates (N-BPs) directly and indirectly prevent proliferation, induce apoptosis, and inhibit metastasis of various types of cancer cell. In order
Tsuyoshi Ohishi et al.
Endocrine research, 42(3), 232-240 (2017-03-21)
Monthly regimen of minodronate for osteoporosis more than two years has not been reported yet. The aim of this study is to elucidate the effect of monthly minodronate (M-MIN) on bone mineral density (BMD) and serum pentosidine (Pen) during 27

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