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S6760

Sigma-Aldrich

Span® 80

nonionic surfactant

Synonym(s):

Sorbitane monooleate, sorbitan oleate

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About This Item

CAS Number:
1338-43-8
EC Number:
215-665-4
MDL number:
MFCD00080948
UNSPSC Code:
12161900
PubChem Substance ID:
24899720
NACRES:
NA.25

Quality Level

200

mol wt

428.62 g/mol

concentration

≥60% (GC)

HLB

4.3

application(s)

microbiology

SMILES string

CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O

InChI

1S/C24H44O6/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-22(27)29-19-21(26)24-23(28)20(25)18-30-24/h9-10,20-21,23-26,28H,2-8,11-19H2,1H3/b10-9-/t20-,21+,23+,24+/m0/s1

InChI key

NWGKJDSIEKMTRX-AAZCQSIUSA-N

General description

Span® 80 is a nonionic surfactant.

Application

Span® 80 has been used in a study to assess transfersomes as a transdermal delivery system for sertraline. It has also been used in a study to investigate the dominant factors affecting the stability of nanoemulsions through the use of artificial neural networks (ANNs).

Other Notes

Fatty acid composition: Oleic acid (C18:1) ≤ 60%; balance primarily linoleic (C18:2), linolenic (C18:3) and palmitic (C16:0) acids.

Legal Information

Span is a registered trademark of Croda International PLC

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Ankit Gupta et al.
Scientia pharmaceutica, 80(4), 1061-1080 (2012-12-25)
The aim of the present study was to investigate transfersomes as a transdermal delivery system for the poorly soluble drug, sertraline, in order to overcome the troubles associated with its oral delivery. Different transfersomal formulations were prepared with non-ionic surfactant
Chenguang Zhou et al.
Molecular pharmaceutics, 9(2), 201-210 (2011-12-14)
Nonionic surfactant vesicles, or SPANosomes (SPs), comprised of cationic lipid and sorbitan monooleate (Span 80) were synthesized and evaluated as small interfering RNA (siRNA) vectors. The SPs had a mean diameter of less than 100 nm and exhibited excellent colloidal
Xiazhong Ren et al.
International journal of pharmaceutics, 431(1-2), 130-137 (2012-05-03)
This study is the first to investigate and demonstrate the potential of microemulsions (MEs) for sustained release parenteral drug delivery, due to phase transition behavior in aqueous environments. Phase diagrams were constructed with Miglyol 812N oil and a blend of
Keita Hayashi et al.
Colloids and surfaces. B, Biointerfaces, 106, 258-264 (2013-02-26)
We have focused on the interaction between the Span 80 vesicle and phospholipid vesicle (liposome). The Span 80 vesicle was mixed with a phospholipid vesicle (liposome), used as a simplified model of plasma membrane. From calcein leakage experiments, it was
Keita Hayashi et al.
International journal of biological sciences, 9(2), 142-148 (2013-02-16)
Span 80 (sorbitan monooleate) vesicles behaved differently from conventional phospholipid vesicles (liposomes) because the former had a more fluid interface. After doxorubicin hydrochloride (DOX) was encapsulated into the Span 80 vesicle (loading efficiency: 63 %), DOX-loaded Span 80 vesicles (DVs)
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