M6545

Mitoxantrone dihydrochloride

≥97% (HPLC)

• Synonym(s): 1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione dihydrochloride
• Empirical Formula (Hill Notation): C₂₂H₂₈N₄O₆ · 2HCl
• CAS Number: 70476-82-3
• Molecular Weight: 517.40
• EC Number: 274-619-1
• MDL number: MFCD00242943
• UNSPSC Code: 12352005
• PubChem Substance ID: 24278562
• NACRES: NA.25

Properties

• Assay: ≥97% (HPLC)
• SMILES string: Cl[H].Cl[H].OCCNCCNc1ccc(NCCNCCO)c2C(=O)c3c(O)ccc(O)c3C(=O)c12
• InChI: 1S/C22H28N4O6.2ClH/c27-11-9-23-5-7-25-13-1-2-14(26-8-6-24-10-12-28)18-17(13)21(31)19-15(29)3-4-16(30)20(19)22(18)32;;/h1-4,23-30H,5-12H2;2*1H
• InChI key: ZAHQPTJLOCWVPG-UHFFFAOYSA-N
• Gene Information: human ... TOP2A(7153)

Description

Application

Mitoxantrone dihydrochloride has been used:

• to induce calreticulin surface expression in cells
• as a genotoxin agent
• as a topoisomerase inhibitor

Biochem/physiol Actions

Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. Mitoxantrone also displays broad immunosuppressive activity inhibiting proliferation of all classes of lymphocytes and inducing apoptosis of antigen-presenting T cells. It used clinically as a chemotherapeutic agent against leukemias and solid tumors and as an immune system modulator in multiple sclerosis.

Safety Information

• Pictograms: GHS08
• Signal Word: Danger
• Hazard Statements: H340,H360
• Precautionary Statements: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Muta. 1B - Repr. 1B
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves