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M0388

Sigma-Aldrich

6α-Methyl-11β-hydroxyprogesterone

Synonym(s):

11β-Hydroxy-6α-methyl-4-pregnene-3,20-dione, Medrysone

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About This Item

Empirical Formula (Hill Notation):
C22H32O3
CAS Number:
2668-66-8
Molecular Weight:
344.49
EC Number:
220-208-7
MDL number:
MFCD00056477
UNSPSC Code:
12352200
PubChem Substance ID:
24896551
NACRES:
NA.77

sterility

non-sterile

form

solid

shipped in

ambient

storage temp.

2-8°C

SMILES string

[H][C@@]12C[C@H](C)C3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@]4(C)[C@H](CC[C@@]24[H])C(C)=O

InChI

1S/C22H32O3/c1-12-9-15-17-6-5-16(13(2)23)22(17,4)11-19(25)20(15)21(3)8-7-14(24)10-18(12)21/h10,12,15-17,19-20,25H,5-9,11H2,1-4H3/t12-,15-,16+,17-,19-,20+,21-,22+/m0/s1

InChI key

GZENKSODFLBBHQ-ILSZZQPISA-N

Gene Information

human ... NR3C1(2908)

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Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Management of vernal conjunctivitis with steroid induced glaucoma--a comparative study.
S Mithal et al.
Indian journal of ophthalmology, 35(5-6), 298-301 (1987-01-01)
N L Verbey et al.
Current eye research, 7(6), 557-561 (1988-06-01)
The effect of topical administration of 3-isobutyl-methyl-xanthine (IBMX), a potent phosphodiesterase inhibitor, was studied on an experimentally provoked uveitis in rabbits. After presensitization with an intravitreal injection of human serum albumin (HSA), intravenous antigenic challenge induces blood-aqueous barrier breakdown and
Efficacy of medrysone as anti-inflammatory agent.
R K Rastogi et al.
Indian journal of ophthalmology, 33(5), 295-297 (1985-09-01)
R B Vajpayee et al.
Australian and New Zealand journal of ophthalmology, 14(3), 251-253 (1986-08-01)
The efficacy of topical sodium cromoglycate and medrysone was evaluated in 38 patients suffering from atopic keratoconjunctivitis. It was found that medrysone (1%) significantly improved the symptoms of itching, watering, photophobia and hyperaemia, while sodium cromoglycate (2%) was found to
K Green et al.
Current eye research, 8(3), 317-320 (1989-03-01)
The interaction between a topically administered progesterone, medrysone, and a steroid antagonist, mifepristone, on rabbit intraocular pressure (IOP) has been determined. Medrysone alone increased IOP significantly above parallel controls over the first three weeks; this increase was not sustained. When
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