I8280

Indomethacin

meets USP testing specifications

• Synonym(s): 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-3-indoleacetic acid
• Empirical Formula (Hill Notation): C₁₉H₁₆ClNO₄
• CAS Number: 53-86-1
• Molecular Weight: 357.79
• Beilstein: 497341
• EC Number: 200-186-5
• MDL number: MFCD00057095
• UNSPSC Code: 12352101
• PubChem Substance ID: 24896136
• NACRES: NA.21

Properties

• Agency: USP/NF; meets USP testing specifications
• Assay: 98.0-102.0%
• form: powder
• Mode of action: enzyme | inhibits
• SMILES string: COc1ccc2n(c(C)c(CC(O)=O)c2c1)C(=O)c3ccc(Cl)cc3
• InChI: 1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23)
• InChI key: CGIGDMFJXJATDK-UHFFFAOYSA-N
• Gene Information: human ... ALB(213) , ALOX5(240) , ELA2(1991) , GPR44(11251) , IL1A(3552) , PLA2G1B(5319) , PTGDR(5729) , PTGS1(5742) , PTGS2(5743) ; mouse ... Alox5(11689) , Ptgdr(19214) , Ptger1(19216) , Ptger2(19217) , Ptger3(19218) , Ptger4(19219) , Ptgs1(19224) , Ptgs2(19225) ; rat ... Alox5(25290) , Ptgs1(24693) , Ptgs2(29527)

Description

Biochem/physiol Actions

Cyclooxygenase (COX) inhibitor that is relatively selective for COX-1.

Used as a non-selective inhibitor of cyclooxygenases, COX1 and COX2, leading to reduced prostaglandin biosynthesis from arachidonic acid.

Safety Information

• Pictograms: GHS06
• Signal Word: Danger
• Hazard Statements: H300
• Precautionary Statements: P264 - P301 + P310
• Hazard Classifications: Acute Tox. 1 Oral
• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves