10385

Angiotensin III trifluoroacetate salt hydrate

≥98% (HPCE)

• Synonym(s): Des-Asp-1-Angiotensin II trifluoroacetate salt hydrate
• Empirical Formula (Hill Notation): C₄₆H₆₆N₁₂O₉ · xC₂HF₃O₂ · yH₂O
• CAS Number: 12687-51-3
• Molecular Weight: 931.09 (anhydrous free base basis)
• Beilstein: 8385695
• MDL number: MFCD20264812
• UNSPSC Code: 12352200
• PubChem Substance ID: 57646800
• NACRES: NA.77

Properties

• Assay: ≥98% (HPCE)
• solubility: H₂O: 1.0 mg/mL, clear, colorless
• storage temp.: −20°C
• SMILES string: O.OC(=O)C(F)(F)F.CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(N)=N)C(C)C)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N3CCC[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(O)=O
• InChI: 1S/C46H66N12O9.C2HF3O2.H2O/c1-5-27(4)38(57-40(61)33(21-29-15-17-31(59)18-16-29)53-42(63)37(26(2)3)56-39(60)32(47)13-9-19-51-46(48)49)43(64)54-34(23-30-24-50-25-52-30)44(65)58-20-10-14-36(58)41(62)55-35(45(66)67)22-28-11-7-6-8-12-28;3-2(4,5)1(6)7;/h6-8,11-12,15-18,24-27,32-38,59H,5,9-10,13-14,19-23,47H2,1-4H3,(H,50,52)(H,53,63)(H,54,64)(H,55,62)(H,56,60)(H,57,61)(H,66,67)(H4,48,49,51);(H,6,7);1H2/t27-,32-,33-,34-,35-,36-,37-,38-;;/m0../s1
• InChI key: JEOAJMGVSAMVML-UFPGTABSSA-N

Description

Amino Acid Sequence

Arg-Val-Tyr-Ile-His-Pro-Phe

General description

Angiotensin III (Ang III) is a 7-AA bioactive peptide that is formed from the degradation of the Angiotensin II peptide by aminopeptidase A; both are derivatives of angiotensinogen and are components of the renin-angiotensin system (RAS).

Biochem/physiol Actions

Angiotensin III is an AT₁ and AT₂ agonist, with higher sensitivity for the AT₂ receptor. Ang III has been shown to be a main effector peptide in RAS-controlled vasopresin release and a stimulator for aldosterone release.

Features and Benefits

This compound is featured on the Angiotensin Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Antibody Adsorbant

Arg-Val-Tyr-Ile-His-Pro-Phe-OH.3CH₃COOH.4H₂O

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves