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Key Documents

SRP3298

Sigma-Aldrich

BMP-4 mouse

recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)

Synonym(s):

BMP-2B, DVR4

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.32

biological source

mouse

recombinant

expressed in E. coli

Assay

≥98% (HPLC)
≥98% (SDS-PAGE)

form

lyophilized

potency

5-15 ng/mL ED50

mol wt

23.8 kDa

packaging

pkg of 10 μg

impurities

<0.1 EU/μg endotoxin, tested

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

mouse ... BMP4(12159)

General description

The gene BMP4 (bone morphogenetic protein 4) encodes a member of the TGFβ (transforming growth factor β) superfamily of intercellular signaling proteins. It is found to be expressed in the extraembryonic ectoderm and mesoderm. E. coli derived murine BMP-4 is a fully active homodimeric protein consisting of two 106 amino acid subunits, which correspond to amino acids 303-408 of the full length BMP-4 precursor.

Application

Bone morphogenetic protein 4 (BMP4) mouse has been used as an agonist for activin A receptor 1 (ALK2) receptors to test the effects of ALK2 activation in cell death.

Biochem/physiol Actions

Bone morphogenetic protein 4 (BMP4) facilitates the the formation of allantois and primordial germ cell precursors in mouse embryo. It participates in hepatic specification in the early embryo. It is critical for the lens-inducing activity of optic vesicle in mouse embryo. BMP4 mediates atrioventricular septation of the mouse heart.

Physical form

Lyophilized from 10 mM Citric Acid.

Reconstitution

Centrifuge the vial prior to opening. Reconstitute in 10 mM Citric Acid to a concentration of 0.1-1.0 mg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Mechanisms of neuroprotection against ischemic insult by stress-inducible phosphoprotein-1/prion protein complex
Beraldo FH, et al.
Journal of Neurochemistry, 145(1), 68-79 (2018)
An essential role of Bmp4 in the atrioventricular septation of the mouse heart.
Jiao K
Genes & Development, 17, 2362-2367 (2003)
BMP-4 is required for hepatic specification of mouse embryonic stem cell-derived definitive endoderm.
Gouon-Evans V
Nature Biotechnology, 24, 1402-1411 (2006)
Flavio H Beraldo et al.
Journal of neurochemistry, 145(1), 68-79 (2017-12-22)
Stress-inducible phosphoprotein 1 (STI1) acts as a neuroprotective factor in the ischemic brain and its levels are increased following ischemia. Previous work has suggested that some of these STI1 actions in a stroke model depend on the recruitment of bone
BMP4 is essential for lens induction in the mouse embryo.
Furuta Y and Hogan BL
Genes & Development, 12, 3764-3775 (1998)

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