P6254

Prednisone

≥98% (HPLC), powder, anti-inflammatory activity

• Synonym(s): 1,4-Pregnadiene-17α,21-diol-3,11,20-trione, 1-Cortisone, 17α,21-Dihydroxy-1,4-pregnadiene-3,11,20-trione, Dehydrocortisone
• Empirical Formula (Hill Notation): C₂₁H₂₆O₅
• CAS Number: 53-03-2
• Molecular Weight: 358.43
• Beilstein: 2065301
• EC Number: 200-160-3
• MDL number: MFCD00003608
• UNSPSC Code: 12352200
• PubChem Substance ID: 24898748
• NACRES: NA.77

Properties

• product name: Prednisone, ≥98%
• biological source: synthetic
• sterility: non-sterile
• Assay: ≥98%
• form: powder
• mp: 236-238 °C (lit.)
• solubility: chloroform/ethanol (1:1): 50 mg/mL, clear, colorless to light yellow
• application(s): hematology
• shipped in: ambient
• storage temp.: room temp
• SMILES string: O=C1C=C[C@@]2(C)C(CC[C@]([C@@](CC[C@@]3(C(CO)=O)O)([H])[C@]3(C)C4)([H])[C@]2([H])C4=O)=C1
• InChI: 1S/C21H26O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-15,18,22,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1
• InChI key: XOFYZVNMUHMLCC-ZPOLXVRWSA-N
• Gene Information: human ... NR3C1(2908)

Description

Application

Prednisone has been used in dimethyl sulfoxide stock suspension to inject into experimental mice and to analyze the effects of glucocorticoid steroid. It has also been used as a test drug, formulated with peanut butter to study the effects of daily administration of MIDD0301, by animal weight, organ weight and haematological analysis.

Biochem/physiol Actions

Prednisone is a synthetic glucocorticoid with anti-inflammatory and immunosuppressive activity. It is useful in treating many disease states and has a half-life of 3.4 to 3.8 hours in plasma. Prednisone is metabolized to prednisolone, which is physiologically active.

Features and Benefits

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Pictograms: GHS08
• Signal Word: Warning
• Hazard Statements: H373
• Precautionary Statements: P260 - P314 - P501
• Hazard Classifications: STOT RE 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves