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C174

Sigma-Aldrich

Corticosterone: HBC complex

≥91.5% (HPLC), free flowing powder, water-soluble stress hormone

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About This Item

CAS Number:
MDL number:
UNSPSC Code:
51111800
NACRES:
NA.77

product name

Corticosterone: HBC complex, free flowing powder

biological source

synthetic (organic)

sterility

non-sterile

Assay

≥91.5% (HPLC)

form

free flowing powder

shipped in

ambient

storage temp.

room temp

InChI

1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1

InChI key

OMFXVFTZEKFJBZ-HJTSIMOOSA-N

Application

Corticosterone: HBC complex has been used:
  • in the intravenous and intraperitoneal administration of corticosterone to rats to test its effect on glucocorticoid and mineralocorticoid activity
  • to induce acute stress in mice
  • in Pulsatile treatment in mice to test its effect on clock gene period 1 transcription

Biochem/physiol Actions

The complex of corticosterone with 2-hydroxypropyl-β-cyclodextrin (HBC) improves water solubility. HBC is a carrier molecule. Corticosterone is a rodent-specific primary adrenal corticosteroid. It displays affinity towards the glucocorticoid and mineralocorticoid receptors.

Reconstitution

Corticosterone content: 66.7 mg/g. When 1 g of complex is reconstituted with water to a total volume of 2.12 mL, a solution which is 90.8 mM in corticosterone is obtained. Corticosterone itself is virtually insoluble in water.

Other Notes

Preformed water-soluble complex of corticosterone and 2-hydroxypropyl-β-cyclodextrin. Package size is total weight of both the corticosterone and the 2-hydroxypropyl-β-cyclodextrin. Corticosterone content: 66.7 mg/g

Pictograms

Health hazardExclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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