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2854

Sigma-Aldrich

Ethylenediaminetetraacetic acid disodium salt solution

2%, solution

Synonym(s):

(Ethylenedinitrilo)tetraacetic acid disodium salt, EDTA disodium salt, EDTA-Na2

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About This Item

Linear Formula:
[-CH2N(CH2CO2Na)CH2CO2H]2
CAS Number:
139-33-3
Molecular Weight:
336.21
Beilstein:
3822669
MDL number:
MFCD00070672
UNSPSC Code:
12352107
PubChem Substance ID:
24857189
NACRES:
NA.77
Pricing and availability is not currently available.

form

solution

Quality Level

200

concentration

2%

storage temp.

2-8°C

SMILES string

[Na+].[Na+].OC(=O)CN(CCN(CC(O)=O)CC([O-])=O)CC([O-])=O

InChI

1S/C10H16N2O8.2Na/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20;;/h1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20);;/q;2*+1/p-2

InChI key

ZGTMUACCHSMWAC-UHFFFAOYSA-L

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General description

Ethylenediamine tetraacetate (EDTA) is a calcium ion chelator,[1] that has a low molecular mass of 292.24 Da.[2]

Application


  • Dual-Responsive Hydrogels for Mercury Ion Detection and Removal from Wastewater.: This study discusses the application of ethylenediaminetetraacetic acid disodium salt in the development of dual-responsive hydrogels, highlighting its effectiveness in detecting and removing mercury ions from wastewater (Diacon et al., 2024).

  • Photocatalytic Hydrogen Evolution Activity of Nitrogen/Fluorine-Codoped Rutile TiO(2).: The article explores the role of ethylenediaminetetraacetic acid disodium salt in enhancing the photocatalytic activity of nitrogen/fluorine-codoped rutile TiO(2) for hydrogen evolution (Miyoshi et al., 2023).

  • High-efficiency cleaning technology and lifespan prediction for the ceramic membrane treating secondary treated effluent.: This study presents a novel cleaning technology involving ethylenediaminetetraacetic acid disodium salt for ceramic membranes, offering insights into efficiency enhancements and lifespan predictions (Lv et al., 2023).

  • Reversible Morphology Locking via Metal Infiltration in a Block Copolymer.: This research investigates the reversible morphology locking of block copolymers facilitated by metal infiltration, using ethylenediaminetetraacetic acid disodium salt as a key component in the process (Ma et al., 2023).

Biochem/physiol Actions

Ethylenediaminetetraacetic acid disodium salt has the ability to block the binding of vasoactive intestinal peptide to macrophage membranes.[1] It is mainly used in the purification of protein, to remove divalent cations and also to prevent protease activity.[2]

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000378386
0000378386
SLCN5447
SLCD0393
SLBX5550

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Ethylenediaminetetraacetic acid disodium salt dihydrate Sigma Grade, suitable for plant cell culture, 98.5-101.5%

Sigma-Aldrich

E6635

Ethylenediaminetetraacetic acid disodium salt dihydrate

Drawbacks of dialysis procedures for removal of EDTA
Monico A, et al.
PLoS ONE, 12(1), e0169843-e0169843 (2017)
Sabina Müller et al.
Methods in molecular biology (Clifton, N.J.), 2654, 463-476 (2023-04-28)
CD8+ cytotoxic T lymphocytes (CTL) play a key role in anti-tumor immune response. They are therefore at the heart of current immunotherapy protocols against cancer. Despite current strategies to potentiate CTL responses, cancer cells can resist CTL attack, thus limiting
Rebecca Wüst et al.
Frontiers in bioengineering and biotechnology, 10, 964705-964705 (2022-10-11)
Vascularization of tissue-engineered constructs remains a key challenge in the field of skeletal muscle tissue engineering. One strategy for vascularizing organoids is in vitro pre-vascularization, relying on de novo assembly of undifferentiated endothelial cells into capillaries, a process termed vasculogenesis.
J J Segura et al.
Journal of endodontics, 22(7), 337-340 (1996-07-01)
The purpose of this study was to investigate the effect of the disodium salt of ethylenediamine tetraacetate (EDTA), a calcium ion chelator used in the root canal therapy, on vasoactive intestinal peptide (VIP) binding to macrophage membranes (MM's). Binding assays
J L D'Amato et al.
Poultry science, 89(5), 938-947 (2010-04-08)
Arginine is an essential amino acid in Aves and is also an important substrate for the immune system. Dietary Arg in avian diets must be sufficient to not only support growth but also immunity. To better understand Arg needs for
View All Related Papers

Questions

1–3 of 3 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. Is it acceptable to use 285-4 after it has been stored at room temperature for 14 days?

    1 answer

    1. The recommended long-term storage for the 2% EDTA solution is at 2-8°C. The product is not considered temperature-sensitive for short-term storage and, therefore, product 285-4 is shipped at ambient temperature. It is stability tested for up to 14 days at ambient temperature. The product is expected to be placed at 2-8°C within 14 days of arrival. If the solution is stored at room temperature for 7 days, it should still be suitable for use. It is advisable to check specimens anticoagulated with 285-4 for signs of clumping or clotting. If any clumping or clotting is observed, the bottle kept at room temperature should be properly disposed of, and a fresh bottle should be ordered.

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