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12620

Sigma-Aldrich

Benzenesulfonyl chloride

for HPLC derivatization

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About This Item

Linear Formula:
C6H5SO2Cl
CAS Number:
Molecular Weight:
176.62
Beilstein:
606926
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22

grade

for HPLC derivatization

Quality Level

vapor pressure

0.04 mmHg ( 20 °C)

Assay

≥99.0% (AT)

form

liquid

refractive index

n20/D 1.551 (lit.)
n20/D 1.551

bp

251-252 °C (lit.)

mp

13-15 °C (lit.)

solubility

alcohol: soluble
cold water: insoluble
diethyl ether: soluble

density

1.384 g/mL at 25 °C (lit.)

cation traces

Al: ≤0.5 mg/kg
Ba: ≤0.1 mg/kg
Bi: ≤0.1 mg/kg
Ca: ≤0.5 mg/kg
Cd: ≤0.05 mg/kg
Co: ≤0.02 mg/kg
Cr: ≤0.02 mg/kg
Cu: ≤0.02 mg/kg
Fe: ≤0.1 mg/kg
K: ≤0.5 mg/kg
Li: ≤0.1 mg/kg
Mg: ≤0.1 mg/kg
Mn: ≤0.02 mg/kg
Mo: ≤0.1 mg/kg
Na: ≤0.5 mg/kg
Ni: ≤0.02 mg/kg
Pb: ≤0.1 mg/kg
Sr: ≤0.1 mg/kg
Zn: ≤0.1 mg/kg

SMILES string

ClS(=O)(=O)c1ccccc1

InChI

1S/C6H5ClO2S/c7-10(8,9)6-4-2-1-3-5-6/h1-5H

InChI key

CSKNSYBAZOQPLR-UHFFFAOYSA-N

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General description

Benzenesulfonyl chloride reacts with Grignard reagent from N-unsubstituted indoles to form oxindoles or substituted indoles.

Application

Benzenesulfonyl chloride was used in one-pot synthesis of dialkyl 1-arylsulfonyl-1,2-dihydroquinoline-2,3-dicarboxylates. It was used as derivatization reagent for the determination of various amines in waste water at the sub-ppb level by gas chromatography-mass spectrometry.

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Pictograms

CorrosionExclamation mark

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - Skin Corr. 1B

Storage Class Code

8A - Combustible corrosive hazardous materials

WGK

WGK 1

Flash Point(F)

260.6 °F

Flash Point(C)

127 °C

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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A facile route to functionalized 1-arylsulfonyl-1, 2-dihydroquinolines.
Yavari I, et al.
Monatshefte fur Chemie / Chemical Monthly, 128(8-9), 927-931 (1997)
Analysis of primary and secondary aliphatic amines in waste water and surface water by gas chromatography-mass spectrometry after derivatization with 2, 4-dinitrofluorobenzene or benzenesulfonyl chloride.
Sacher F, et al.
Journal of Chromatography A, A764(1), 85-93 (1997)
Unusual reactions of magnesium indolates with benzenesulfonyl chloride.
Wenkert E, et al.
The Journal of Organic Chemistry, 52(15), 3404-3409 (1987)
A G Soliman
Journal - Association of Official Analytical Chemists, 64(3), 616-622 (1981-05-01)
A semiautomated procedure was used to measure the fluorescence of sample extracts before and after the addition of benzenesulfonyl chloride (BSC). Addition of BSC inhibited thiochrome formation and provided a more representative blank based on the fluorescence of all the
A Leone-Bay et al.
Journal of medicinal chemistry, 38(21), 4257-4262 (1995-10-13)
A series of benzoylated and phenylsulfonylated amino acids are novel, low molecular weight, self-assembling molecules. At low pH, these compounds form microspheres that dissolve readily under neutral conditions. In a given synthetic series, those molecules with low aqueous solubility formed

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