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Key Documents

SML3865

Sigma-Aldrich

BAY-805

≥98% (HPLC)

Synonym(s):

BAY 805, BAY805, N-[(1R)-1-[[5-[(4-Cyanophenyl)methyl]-1,3,4-thiadiazol-2-yl]-carbamoyl]-3-methyl-butyl]-1-(trifluoromethyl)-cyclohexanecarboxamide

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About This Item

Empirical Formula (Hill Notation):
C24H28F3N5O2S
CAS Number:
Molecular Weight:
507.57
MDL number:
UNSPSC Code:
41115709
NACRES:
NA.77

Quality Level

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

Biochem/physiol Actions

Potent and selective dual USP21 deubiquitinase (DUB) inhibitor with anti-cancer efficacy.

BAY-805 is a higly potent and selective USP21 deubiquitinase (DUBs) inhibitor (IC50 (Emax) = 6 nM (95%) by HTRF assay, 2 nM (87%) by Ub-Rh110 assay; Kd = 2.2 nM by SPR-based competition assay; 50/53% inhibition of USP10/USP22 at 10 µM, <31% inhibition against other DUBs) that effectively upregulates cellular NF-κB activation (7-fold increase at 10 µM 20h post BAY-805 treatment by HEK293T-based reporter assay) with good target engagement (EC50 = 17 nM by USP21 HiBiT CESTA assay).

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

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Fabian Göricke et al.
Journal of medicinal chemistry, 66(5), 3431-3447 (2023-02-22)
USP21 belongs to the ubiquitin-specific protease (USP) subfamily of deubiquitinating enzymes (DUBs). Due to its relevance in tumor development and growth, USP21 has been reported as a promising novel therapeutic target for cancer treatment. Herein, we present the discovery of

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