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Key Documents

SML0915

Sigma-Aldrich

Xipamide

≥98% (HPLC)

Synonym(s):

5-(Aminosulfonyl)-4-chloro-N-(2,6-dimethylphenyl)-2-hydroxy-benzamide, BE 1293, BEI 1293, MJF 10938

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About This Item

Empirical Formula (Hill Notation):
C15H15ClN2O4S
CAS Number:
14293-44-8
Molecular Weight:
354.81
EC Number:
238-216-4
UNSPSC Code:
12352200
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

−20°C

InChI

1S/C15H15ClN2O4S/c1-8-4-3-5-9(2)14(8)18-15(20)10-6-13(23(17,21)22)11(16)7-12(10)19/h3-7,19H,1-2H3,(H,18,20)(H2,17,21,22)

InChI key

MTZBBNMLMNBNJL-UHFFFAOYSA-N

Biochem/physiol Actions

Xipamide is a sulfonamide diuretic that blocks sodium reabsorption in the distal tubules of the kidney, resulting in increased urine output. Xiopamide also blocks the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Xipamide induced symptomatic severe hyponatraemia.
S C Mishra et al.
The Journal of the Association of Physicians of India, 39(2), 229-230 (1991-02-01)
Anton Sandhofer et al.
Wiener klinische Wochenschrift, 114(21-22), 938-942 (2003-01-17)
Diuretics are among the most frequently prescribed substances in elderly patients, but they are also associated with the highest incidence of adverse effects in this group of patients. Xipamide is a sulfonamide-like diuretic whose action does not depend on transtubular
U Akesolo et al.
Journal of chromatographic science, 42(2), 74-79 (2004-03-17)
Experimental design methodologies are applied to the development of a capillary zone electrophoretic method for the separation of the angiotensin-converting enzyme inhibitor enalapril and its derivative enalaprilat and the diuretics xipamide and hydrochlorothiazide. The effects of pH, buffer concentration, proportion
[Proven in the practice. Follow up of the use confirms high trial value].
MMW Fortschritte der Medizin, 145(51-52), 37-37 (2004-02-21)
[What did the ALLHAT study bring? To do the one without foregoing the other].
MMW Fortschritte der Medizin, 145(51-52), 36-37 (2004-02-21)
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