M4667

(±)-Mevalonolactone

~97% (titration)

• Synonym(s): (±)-β-Hydroxy-β-methyl-δ-valerolactone, (±)-3-Hydroxy-3-methyl δ-valerolactone, DL-Mevalolactone, DL-Mevalonic acid lactone
• Empirical Formula (Hill Notation): C₆H₁₀O₃
• CAS Number: 674-26-0
• Molecular Weight: 130.14
• Beilstein: 80960
• EC Number: 211-615-0
• MDL number: MFCD00006648
• UNSPSC Code: 12352108
• PubChem Substance ID: 24896934
• NACRES: NA.25

Properties

• Assay: ~97% (titration)
• storage temp.: −20°C
• SMILES string: CC1(O)CCOC(=O)C1
• InChI: 1S/C6H10O3/c1-6(8)2-3-9-5(7)4-6/h8H,2-4H2,1H3
• InChI key: JYVXNLLUYHCIIH-UHFFFAOYSA-N

Description

General description

Alkaline hydrolysis of mevalonolactone gives mevalonate. Mevalonate is a precursor of farnesyl and geranylgeranyl pyrophosphates. These pyrophosphates are required for protein prenylation.

Application

(±)-Mevalonolactone is used to:

• study the effect of statin on the prenylation of Ras and Rho GTPases
• analyse the isoprenoid biosynthesis pathways in Listeria monocytogenes
• study the the effects of statins on proliferation and migration of HUVECs (HGF-induced human umbilical vein endothelial cells)

Other Notes

May also be liquid!

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): 235.4 °F - closed cup
• Flash Point(C): 113 °C - closed cup
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves