M0880

Ethyl methanesulfonate

liquid

• Synonym(s): Ethyl mesylate, Methanesulfonic acid ethyl ester
• Linear Formula: CH₃SO₃CH₂CH₃
• CAS Number: 62-50-0
• Molecular Weight: 124.16
• Beilstein: 773969
• EC Number: 200-536-7
• MDL number: MFCD00007559
• UNSPSC Code: 12352108
• PubChem Substance ID: 24896575
• NACRES: NA.25

Properties

• form: liquid
• refractive index: n20/D 1.418 (lit.)
• bp: 85-86 °C/10 mmHg (lit.)
• density: 1.206 g/mL at 20 °C
• SMILES string: CCOS(C)(=O)=O
• InChI: 1S/C3H8O3S/c1-3-6-7(2,4)5/h3H2,1-2H3
• InChI key: PLUBXMRUUVWRLT-UHFFFAOYSA-N

Description

Application

Ethyl methanesulfonate had been used for inducing mutation in mouse embryonic fibroblasts, yeast human embryonic kidney cell lines and human lymphocytes.

Biochem/physiol Actions

Ethyl methanesulfonate is a DNA ethylating agent, mutagenic to plants and animals and carcinogenic in mammals. It has been used as a model alkylating agent in studies of DNA repair processes. EMS induces base substitutions of guanine-cytosine (G/C) to adenine-thymine (A/T). EMS also generates point mutations and single nucleotide polymorphisms in genomes. EMS is potential chemical mutagen used for inducing mutation in rice, wheat and Arabidopsis thaliana.

Safety Information

• Pictograms: GHS08,GHS07
• Signal Word: Danger
• Hazard Statements: H302,H315,H317,H319,H340,H350,H361f
• Precautionary Statements: P202 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Carc. 1B - Eye Irrit. 2 - Muta. 1B - Repr. 2 - Skin Irrit. 2 - Skin Sens. 1
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point(F): 212.0 °F
• Flash Point(C): 100 °C
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves