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H2529

Sigma-Aldrich

α-Hydroxytriazolam

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About This Item

Empirical Formula (Hill Notation):
C17H12Cl2N4O
CAS Number:
37115-45-0
Molecular Weight:
359.21
MDL number:
MFCD00467159
UNSPSC Code:
12352200
PubChem Substance ID:
24895508
NACRES:
NA.77

drug control

regulated under CDSA - not available from Sigma-Aldrich Canada

Quality Level

200

SMILES string

OCc1nnc2CN=C(c3ccccc3Cl)c4cc(Cl)ccc4-n12

InChI

1S/C17H12Cl2N4O/c18-10-5-6-14-12(7-10)17(11-3-1-2-4-13(11)19)20-8-15-21-22-16(9-24)23(14)15/h1-7,24H,8-9H2

InChI key

BHUYWUDMVCLHND-UHFFFAOYSA-N

Biochem/physiol Actions

Triazolam metabolite

Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Warning

Hazard Statements

H302 + H312 + H332,H361fd

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Repr. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Jin, L., et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 654, 77-77 (1994)
Kenji Tsujikawa et al.
Journal of analytical toxicology, 29(4), 240-243 (2005-06-25)
The objective of this study was to examine urinary excretion profiles of two major triazolam metabolites, alpha-hydroxytriazolam (alpha-OHTRZ) and 4-hydroxytriazolam (4-OHTRZ) in humans. Urine samples were collected from three healthy male volunteers who had been previously administered single 0.25- and
F S Eberts et al.
Clinical pharmacology and therapeutics, 29(1), 81-93 (1981-01-01)
Triazolam (T) is a new, potent hypnotic with a short duration of action in man. After an 0.88-mg oral dose of T-14C in six male subjects, mean recovery of 14C radioactivity was 85% in urine and 8% in feces. The
A D Fraser et al.
Journal of analytical toxicology, 16(6), 347-350 (1992-11-01)
Triazolam is a very short-acting triazolobenzodiazepine with sedative-hypnotic properties. Approximately 2% of an oral dose is excreted unchanged in the urine. The major urinary metabolite is alpha-hydroxytriazolam glucuronide (70% of the dose). The objective of this study was to characterize
Dora Farkas et al.
Journal of clinical pharmacology, 47(3), 286-294 (2007-02-27)
The effect of pomegranate juice (PJ) or grapefruit juice (GFJ) on CYP3A activity was studied in vitro and in healthy human volunteers. In human liver microsomes, the mean 50% inhibitory concentrations (IC(50)) for PJ and GFJ versus CYP3A (triazolam alpha-hydroxylation)
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