The cyclin B1 (CCNB1) gene is mapped to human chromosome 5q13.2. The gene codes for a 62kDa protein containing a classical cyclin box domain. CCNB1 shuttles between the nucleus and cytoplasm until prophase begins. It is a member of the cyclin family and is expressed at low levels in normal cells.
Immunogen
recombinant hamster cyclin B1
Application
Anti-cyclin B1 antibody produced in rabbit has been used in western blotting.
Biochem/physiol Actions
Cyclin B1 (CCNB1) and cyclin-dependent kinase 1 (CDK1) complex play a crucial role in regulation of mitosis. Elevated expression of the gene has been observed in various types of human cancers including breast, lung, colon, prostate and head and neck cancers. Thus, this protein can be considered as a potent target for cancer vaccines. In addition, CCNB1 also serves as a prognostic biomarker for estrogen-receptor-positive (ER+) breast cancer.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide
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The Journal of reproduction and development, 53(6), 1151-1157 (2007-08-19)
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