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A9202

Sigma-Aldrich

Angiotensin Fragment 1-7 acetate salt hydrate

≥90% (HPLC), powder, RAS heptapeptide

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About This Item

Empirical Formula (Hill Notation):
C41H62N12O11 · xC2H4O2 · yH2O
Molecular Weight:
899.00 (anhydrous free base basis)
MDL number:
UNSPSC Code:
12352202
PubChem Substance ID:
NACRES:
NA.77

product name

Angiotensin Fragment 1-7 acetate salt hydrate, ≥90% (HPLC), powder

Quality Level

Assay

≥90% (HPLC)

form

powder

UniProt accession no.

storage temp.

−20°C

SMILES string

CCC(C)C(NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(NC(=O)C(CCCNC(N)=N)NC(=O)C(N)CC(O)=O)C(C)C)C(=O)NC(Cc2cnc[nH]2)C(=O)N3CCCC3C(O)=O

InChI

1S/C41H62N12O11/c1-5-22(4)33(38(61)50-29(17-24-19-45-20-47-24)39(62)53-15-7-9-30(53)40(63)64)52-36(59)28(16-23-10-12-25(54)13-11-23)49-37(60)32(21(2)3)51-35(58)27(8-6-14-46-41(43)44)48-34(57)26(42)18-31(55)56/h10-13,19-22,26-30,32-33,54H,5-9,14-18,42H2,1-4H3,(H,45,47)(H,48,57)(H,49,60)(H,50,61)(H,51,58)(H,52,59)(H,55,56)(H,63,64)(H4,43,44,46)

InChI key

PVHLMTREZMEJCG-UHFFFAOYSA-N

Gene Information

human ... AGT(183)

Amino Acid Sequence

Asp-Arg-Val-Tyr-Ile-His-Pro

Application

Angiotensin Fragment 1-7 acetate salt hydrate has been used:
  • to evaluate its effects on a rat model of ventilator-induced diaphragmatic dysfunction (VIDD) with neuromuscular blocking agent infusion
  • to unilaterally inject into the lateral preoptic area (LPA) to study its effects on intravesical pressure, arterial pressure, heart rate, and renal conductance in the female rats
  • to study its association with influenza A virus (IAV) infection

Biochem/physiol Actions

Angiotensin fragment 1-7 is a biologically active heptapeptide of the renin-angiotensin system (RAS). It is associated with anti-inflammatory and anti-fibrotic effects in many inflammatory diseases such as asthma, dyslipidemia, renal injury, arthritis, and lung fibrosis. Angiotensin fragment 1-7 acts as a pro-resolving mediator and induces resolution of inflammation via Mas receptor (MasR). It is responsible for relaxation in several vascular beds. Angiotensin fragment 1-7 has a dual action of an angiotensin II type 1 (AT1) receptor agonist and antagonist depending on the presence of angiotensin II. It also serves as a substrate for angiotensin-converting enzyme (ACE). Sometimes, angiotensin fragment 1-7 prevents ACE activity leading to decreased angiotensin II generation and improved bradykinin-induced vasodilatation.

Other Notes

Lyophilized from 0.5% acetic acid

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Vanessa Zambelli et al.
Intensive care medicine experimental, 7(1), 8-8 (2019-01-20)
Ventilator-induced diaphragmatic dysfunction (VIDD) is a common event during mechanical ventilation (MV) leading to rapid muscular atrophy and contractile dysfunction. Recent data show that renin-angiotensin system is involved in diaphragmatic skeletal muscle atrophy after MV. In particular, angiotensin-II can induce
Eliza M Melo et al.
Pharmacological research, 163, 105292-105292 (2020-11-11)
Resolution failure of exacerbated inflammation triggered by Influenza A virus (IAV) prevents return of pulmonary homeostasis and survival, especially when associated with secondary pneumococcal infection. Therapeutic strategies based on pro-resolving molecules have great potential against acute inflammatory diseases. Angiotensin-(1-7) [Ang-(1-7)]
S Y Osei et al.
European journal of pharmacology, 234(1), 35-42 (1993-03-30)
Regional vascular responses to angiotensin (Ang)-(1-7), a heptapeptide derivative of Ang II were investigated in the feline hindquarters and mesenteric vascular beds under conditions of controlled flow. In the mesenteric vascular bed, injections of Ang-(1-7) in doses of 1, 3
C Caruso-Neves et al.
Biochimica et biophysica acta, 1467(1), 189-197 (2000-08-10)
Angiotensin-(1-7) (Ang-(1-7)) modulates the Na+-ATPase, but not the Na+,K+-ATPase activity present in pig kidney proximal tubules. The Na+-ATPase, insensitive to ouabain, but sensitive to furosemide, is stimulated by Ang-(1-7) (68% by 10(-9) M), in a dose-dependent manner. This effect is
Joep H M van Esch et al.
European journal of pharmacology, 588(2-3), 286-293 (2008-05-31)
Aminopeptidases metabolize angiotensin II to angiotensin-(2-8) (=angiotensin III) and angiotensin-(3-8) (=angiotensin IV), and carboxypeptidases generate angiotensin-(1-7) from angiotensin I and II. Angiotensin-converting enzyme (ACE) inhibitors and/or angiotensin II type 1 (AT1) receptor blockers affect the concentrations of these metabolites, and

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