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04473

2,4-Pyridinedicarboxylic acid

Name: 2,4-Pyridinedicarboxylic acid
Brand: SIGMA

≥98.0%

Synonym(s):

Lutidinic acid

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About This Item

Empirical Formula (Hill Notation):

C₇H₅NO₄

CAS Number:

499-80-9

Molecular Weight:

167.12

NACRES:

NA.25

PubChem Substance ID:

329747930

UNSPSC Code:

12352106

EC Number:

207-892-2

MDL number:

MFCD00006296

Beilstein/REAXYS Number:

131631

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Properties

Quality Segment

100

assay

≥98.0%, 98.0-102.0% (T)

InChI

1S/C7H5NO4/c9-6(10)4-1-2-8-5(3-4)7(11)12/h1-3H,(H,9,10)(H,11,12)

InChI key

MJIVRKPEXXHNJT-UHFFFAOYSA-N

Description

Application

2,4-Pyridinedicarboxylic acid is an in vitro and in cell inhibitor, as well as a known inhibitor of the histone lysine demethylases. 2,4-Pyridinedicarboxylic acid has been used in a study to determine that ruthenium(II) complexes exert antimetastatic effects on several tumor cell lines in vitro, achieved mostly by the effect on cell adhesion, migration and angiogenesis. . 2,4-Pyridinedicarboxylic acid has been used in a study to develop an assay that represents the first report of a RapidFire mass spectrometery assay for an epigenetics target.

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Inhibitors of 2-ketoglutarate-dependent dioxygenases block aspartyl beta-hydroxylation of recombinant human factor IX in several mammalian expression systems.

C K Derian et al.

The Journal of biological chemistry, 264(12), 6615-6618 (1989-04-25)

While a role has been ascribed to the gamma-carboxyglutamate (Gla) residues in vitamin K-dependent coagulation proteins and the enzyme catalyzing this posttranslational modification has been identified and partially characterized, both the functional significance of a second posttranslationally synthesized amino acid

Self-referencing intensity measurements based on square-wave gated phase-modulation fluorimetry.

H M Rowe et al.

Applied spectroscopy, 57(5), 532-537 (2003-12-09)

An adaptation of square-wave gated phase-modulation (GPM) fluorimetry allows for self-referenced intensity measurements without the complexity of dual excitation or dual emission wavelengths. This AC technique utilizes square-wave excitation, gated detection, a reference emitter, and a sensor molecule. The theory

Synthesis, characterization and fluorescence properties of novel pyridine dicarboxylic acid derivatives and corresponding Tb(III) complexes.

Guo-liang Gu et al.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 71(1), 209-214 (2008-02-19)

Two novel ligands containing two pyridine-2,6-dicarboxylic acid conjugative units, 4-(2-(2,6-dicarbox-ypyridin-4-yl)vinyl)pyridine-2,6-dicarboxylic acid (L1) and 4-(4-(2-(2,6-dicarboxypyridin-4-yl)vinyl)styryl)pyridine-2,6-dicarboxylic acid (L2) and their complexes with Tb(III) have been synthesized and characterized by elemental analysis, IR spectra and NMR. The ligand synthetic route was optimized and

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Global Trade Item Number

SKU	GTIN
143618-500G	04061832278599
143618-100G	04061838734921
04473-5G	04061838630681