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21980

Sigma-Aldrich

Cardiogreen

for microscopy

Synonym(s):

Foxgreen, IC Green, Indocyanine green

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About This Item

Empirical Formula (Hill Notation):
C43H47N2NaO6S2
CAS Number:
3599-32-4
Molecular Weight:
774.96
Beilstein:
4115884
EC Number:
222-751-5
MDL number:
MFCD00013078
UNSPSC Code:
12171500
PubChem Substance ID:
329752231
NACRES:
MA.02

grade

for microscopy

Quality Level

200

form

powder

color

green to very dark green

solubility

water: 0.01 g/10 mL

ε (extinction coefficient)

≥115 at 386-396 nm in water
≥2000 at 774-784 nm in water
≥900 at 712-722 nm in water

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

SMILES string

[Na+].CC1(C)/C(=C\C=C\C=C\C=C\C2=[N+](CCCCS([O-])(=O)=O)c3ccc4ccccc4c3C2(C)C)N(CCCCS([O-])(=O)=O)c5ccc6ccccc6c15

InChI

1S/C43H48N2O6S2.Na/c1-42(2)38(44(28-14-16-30-52(46,47)48)36-26-24-32-18-10-12-20-34(32)40(36)42)22-8-6-5-7-9-23-39-43(3,4)41-35-21-13-11-19-33(35)25-27-37(41)45(39)29-15-17-31-53(49,50)51;/h5-13,18-27H,14-17,28-31H2,1-4H3,(H-,46,47,48,49,50,51);/q;+1/p-1

InChI key

MOFVSTNWEDAEEK-UHFFFAOYSA-M

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General description

Cardiogreen is a dye used for microscopy. This dye has its maximum extinction at the same wavelength as reduced and oxygenated haemoglobin meet making it possible to record the oxygen saturation in blood. This dye has no side-effects.

Application

Cardiogreen was injected in animals intravenously for dynamic optical imaging system to study the capability of capturing the in vivo biodistribution kinetics.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

A diagnostic aid in the determination of hepatic function

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCK2318
BCCH0322
BCCC8759
BCCC3884
BCCB1698

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Elizabeth M C Hillman et al.
Nature photonics, 1(9), 526-530 (2008-11-01)
Optical molecular imaging in small animals harnesses the power of highly specific and biocompatible contrast agents for drug development and disease research1-7. However, the widespread adoption of in vivo optical imaging has been inhibited by its inability to clearly resolve
C.M. Leevy et al.
Probl. Liver Dis. (Review), 42-42 (1979)
Ran Tivony et al.
Journal of biomedical nanotechnology, 10(6), 1041-1048 (2014-04-23)
In this paper we describe the preparation of novel Near Infrared (NIR) fluorescent nanoparticles for application in medical imaging of colorectal tumors. The nanoparticles are prepared by using only non-covalent binding processes of molecules which are approved for clinical use.
H M Mathéron et al.
Gynecologic oncology, 131(3), 720-725 (2013-09-21)
Conventional sentinel node (SN) mapping is performed by injecting a radiocolloid followed by lymphoscintigraphy (and SPECT/CT imaging). An extra intraoperative injection with blue dye can then allow for optical identification of the SN. In order to improve the current clinical
Michele Diana et al.
Annals of surgery, 259(4), 700-707 (2013-03-28)
Our aim was to evaluate a fluorescence-based enhanced-reality system to assess intestinal viability in a laparoscopic mesenteric ischemia model. A small bowel loop was exposed, and 3 to 4 mesenteric vessels were clipped in 6 pigs. Indocyanine green (ICG) was
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