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935921

Sigma-Aldrich

Poly(glycerol sebacate)

Synonym(s):

PGS

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About This Item

Linear Formula:
[CH2CH(OH)CH2OOC(CH2)8COO]n
UNSPSC Code:
12352201
NACRES:
NA.21

form

solid

Quality Level

100

color

colorless to yellow

General description

Poly(glycerol sebacate) (PGS) is a biodegradable polymer with tunable mechanical properties that can be used in soft tissue engineering and regenerative medicine applications. It is non-immunogenic, non-cytotoxic and has minimal inflammatory response. The polymer backbone and crosslinks can undergo hydrolytic degradation due to the presence of ester linkages. The ester bonds in the polymer backbone covalently crosslink at high temperature (>130 °C) under vacuum without using any toxic crosslinkers to form a three-dimensional (3D) network of random coils.

Application

  • Scaffold material synthesis like blood vessels, cornea and nerve tissue
  • In orthopedic implants
  • In the drug delivery system and bioelectronic applications

Features and Benefits

  • Flexible elastomer with tunable mechanical properties
  • Higher reversible deformation properties
  • Shape memory
  • Bioresorbable polymer

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Poly(Glycerol Sebacate) in Biomedical Applications-A Review of the Recent Literature
Vogt L, et al.
Advanced Healthcare Materials, 10, e2002026-e2002026 (2021)
Synthesis, Characterization and 3D Micro-Structuring via 2-Photon Polymerization of Poly(glycerol sebacate)-Methacrylate?An Elastomeric Degradable Polymer
Tala, et al.
Frontiers in physics, 6, 41-41 (2018)

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