The SPME-LC fiber probes are intended as single-use devices for the extraction of small molecules out of a fluid followed by solvent desorption and LC analysis.
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Journal of pharmaceutical and biomedical analysis, 47(4-5), 907-912 (2008-05-13)
Pharmacokinetic (PK) studies in rats typically involve removal of serial blood samples following dosing. This research illustrates the development of a fast in vivo microextraction technique that has the potential to partly replace current sampling techniques based on blood draws
Metabolomics and biomarkers discovery are an integral part of bioanalysis. However, untargeted tissue analysis remains as the bottleneck of such studies due to the invasiveness of sample collection, as well as the laborious and time-consuming sample preparation protocols. In the
Journal of chromatography. A, 1217(25), 4041-4060 (2009-12-25)
The primary objective of this review is to discuss recent technological developments in the field of solid-phase microextraction that have enhanced the utility of this sample preparation technique in the field of bioanalysis. These developments include introduction of various new
The success of in vivo solid phase microextraction (SPME) depends significantly on the selection of calibration method. Three kinetic in vivo SPME calibration methods are evaluated in this paper: (1) on-fibre standardization (OFS), (2) dominant pre-equilibrium desorption (DPED), and (3)
Journal of pharmaceutical and biomedical analysis, 54(5), 926-950 (2011-01-05)
Biomedical analyses of drugs, metabolites, poisons, environmental and occupational pollutants, disease biomarkers and endogenous substances in body fluids and tissues are important in the development of new drugs, therapeutic monitoring, forensic toxicology, patient diagnosis, and biomonitoring of human exposure to
Accurate protein binding affinities were measured using bioSPME more rapidly than membrane dialysis (RED) techniques. Binding affinities correlated to the reference values.
A demonstration of the use of innovative BioSPME fibers for the selective extraction of drugs and polar metbolites from biological matrices.
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