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T4143

Sigma-Aldrich

Triamterene

≥99%

Synonym(s):

2,4,7-Triamino-6-phenylpteridine, 6-Phenyl-2,4,7-pteridinetriamine

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About This Item

Empirical Formula (Hill Notation):
C12H11N7
CAS Number:
396-01-0
Molecular Weight:
253.26
EC Number:
206-904-3
MDL number:
MFCD00006708
UNSPSC Code:
12352200
PubChem Substance ID:
24277877
NACRES:
NA.77

Assay

≥99%

solubility

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: soluble 1.2 mg/mL
DMSO: soluble 5.4 mg/mL
H2O: insoluble

originator

Wellspring

SMILES string

Nc1nc(N)c2nc(-c3ccccc3)c(N)nc2n1

InChI

1S/C12H11N7/c13-9-7(6-4-2-1-3-5-6)16-8-10(14)18-12(15)19-11(8)17-9/h1-5H,(H6,13,14,15,17,18,19)

InChI key

FNYLWPVRPXGIIP-UHFFFAOYSA-N

Gene Information

human ... SCNN1A(6337) , SCNN1B(6338) , SCNN1G(6340)

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Application

Triamterene has been used to study its effects on urokinase receptor (uPAR) induction in podocytes under in vitro conditions2. Triamterene has also been identified as an activator compound from a LOPAC library screen using a fluorogenic α-glucosidase assay3.

Biochem/physiol Actions

Weak diuretic with potassium sparing properties; blocks Na+ reuptake in the kidneys.

Features and Benefits

This compound was developed by Wellspring. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Preparation Note

200 mg of triamterene is soluble in 4 ml of warm formic acid and yields a clear, yellow-green solution. Triamterene is also soluble in DMSO (5.4 mg/ml), and in 45% (w/v) aqueous 2-hydroxypropyl-β-cyclodextrin (1.2 mg/ml). However, it is insoluble in water.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302,H315,H319,H335

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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A fixed-dose combination (FDC) of four compounds, hydrochlorothiazide 12.5 mg, triamterene 12.5 mg, dihydralazine 12.5 mg and reserpine 0.1 mg (HTDR), is widely used as an antihypertensive treatment in China. Although HTDR has been used in China for more than
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Potassium-sparing diuretics, which block the epithelial sodium channel (ENaC), are widely prescribed for hypertension as a second-line drug in patients taking other diuretics (e.g. thiazide diuretics) and much less commonly prescribed as monotherapy. Therefore, it is essential to determine the
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The use of a light induced fluorescence (LIF) instrument to estimate the total content of fluorescent active pharmaceutical ingredient in a tablet from surface sampling was demonstrated. Different LIF sampling strategies were compared to a total tablet ultraviolet (UV) absorbance
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