SRP8035

IL-36α mouse

recombinant, expressed in E. coli, untagged, >95% (SDS-PAGE)

• Synonym(s): Interleukin-1 family member 6, Interleukin-1 homolog 1, Interleukin-1α, Interleukin-36α
• UNSPSC Code: 12352202
• NACRES: NA.32

Properties

• biological source: mouse
• recombinant: expressed in E. coli
• conjugate: untagged
• Assay: >95% (SDS-PAGE)
• form: lyophilized
• mol wt: ~17 kDa
• packaging: pkg of 10 μg
• impurities: <0.01 EU/μg endotoxin, tested
• UniProt accession no.: Q9JLA2
• shipped in: wet ice
• storage temp.: −20°C
• Gene Information: mouse ... Il36a(54448)

Description

General description

IL-36α (IL-1F6), IL-36β (IL-1F8) and IL-36γ (IL-1F9) bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1. IL-36Ra inhibits the production of proinflammatory cytokines, including IL-12, IL-1β, IL-6, TNF-α and IL-23 induced by IL-36 in BMDC and CD4 T cells. Skin and dendritic cells are targets of the IL-36 interleukins leading to a Th1 response. These cytokines may represent potential targets for immune-mediated inflammatory conditions or, alternatively, could be used as adjuvants in vaccination.

Physical form

Lyophilized from PBS.

Reconstitution

Reconstitute with 100 μL deionized water.

Other Notes

IL-36alpha (mouse) (aa 8-160) is untagged.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable