SRP6099
GSTM1 from mouse
recombinant, expressed in E. coli, ≥95% (SDS-PAGE)
Synonym(s):
GST 1-1, GST class-mu1, Glutathione S-transferase Mu 1, pmGT10
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About This Item
UNSPSC Code:
12352200
NACRES:
NA.32
biological source
mouse
recombinant
expressed in E. coli
Assay
≥95% (SDS-PAGE)
form
liquid
mol wt
25.9 kDa
packaging
pkg of 100 μg
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
mouse ... GSTM1(14862)
General description
GSTM1 (glutathione S-transferase μ 1) belongs to the superfamily of glutathione-S-transferases. It belongs to the μ class of soluble GSTs. GSTM1 is strongly expressed in the kidneys.[1]
Biochem/physiol Actions
Members of GST (glutathione S-transferase) superfamily are responsible for the metabolism of various reactive oxygen species and xenobiotics. GSTM1 (GST μ 1) plays a significant role in vascular homeostasis. Humans with null allele, GSTM1(0), are at increased risks for colon and lung cancers, hypertension, and atherosclerosis, and have higher DNA changes in atherosclerotic lesions of the abdominal aorta.[1]
Physical form
1 mg/mL solution in PBS (pH 7.4) containing 5 mM Glutathione
Preparation Note
Centrifuge the vial prior to opening.
Other Notes
MPMILGYWNV RGLTHPIRML LEYTDSSYDE KRYTMGDAPD FDRSQWLNEK FKLGLDFPNL PYLIDGSHKI TQSNAILRYL ARKHHLDGET EEERIRADIV ENQVMDTRMQ LIMLCYNPDF EKQKPEFLKT IPEKMKLYSE FLGKRPWFAG DKVTYVDFLA YDILDQYRMF EPKCLDAFPN LRDFLARFEG LKKISAYMKS SRYIATPIFS KMAHWSNK
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Glutathione S-transferase-micro1 regulates vascular smooth muscle cell proliferation, migration, and oxidative stress.
Yang Y, et al.
Hypertension, 54, 1360-1360 (2009)
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