SRP0314
FBXL11 human
recombinant, expressed in baculovirus infected Sf9 cells, ≥15% (SDS-PAGE)
Synonym(s):
FBL7, FBXL11, JHDM1A, KDM2A, lysine (K)-specific demethylase 2A
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About This Item
UNSPSC Code:
12352202
NACRES:
NA.32
biological source
human
recombinant
expressed in baculovirus infected Sf9 cells
Assay
≥15% (SDS-PAGE)
form
aqueous solution
mol wt
82 kDa
packaging
pkg of 20 μg
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... KDM2A(22992)
General description
Human F-Box Protein 11 (FBXL11), also known as KDM2A, Ndy2, and JHDM1A GenBank Accession # NM_012308, a.a. 2-700 with N-terminal FLAGAvi- tag, MW = 82 kDa, expressed in Sf9 cells via a baculovirus expression system.
Application
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Analysis Note
Specific Activity: 0.01 pmole/min/μg using BPS Bioscience FBXL11 Homogeneous Assay Kit (Cat. No. 50611)
Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Neil P Blackledge et al.
Molecular cell, 38(2), 179-190 (2010-04-27)
In higher eukaryotes, up to 70% of genes have high levels of nonmethylated cytosine/guanine base pairs (CpGs) surrounding promoters and gene regulatory units. These features, called CpG islands, were identified over 20 years ago, but there remains little mechanistic evidence
Yuji Tanaka et al.
The EMBO journal, 29(9), 1510-1522 (2010-04-10)
The rate-limiting step in ribosome biogenesis is the transcription of ribosomal RNA, which is controlled by environmental conditions. The JmjC enzyme KDM2A/JHDM1A/FbxL11 demethylates mono- and dimethylated Lys 36 of histone H3, but its function is unclear. Here, we show that
David Frescas et al.
Cell cycle (Georgetown, Tex.), 7(22), 3539-3547 (2008-11-13)
Heterochromatin plays an essential role in the preservation of epigenetic information, the transcriptional repression of repetitive DNA elements and inactive genes, and the proper segregation of chromosomes during mitosis. Here we identify KDM2A, a JmjC-domain containing histone demethylase, as a
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