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SML2537

Sigma-Aldrich

NSAH

≥98% (HPLC)

Synonym(s):

2-Hydroxy-benzoic acid (2E)-2-[(2-hydroxy-1-naphthalenyl)methylene]hydrazide

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5 MG
$113.00
25 MG
$363.00

$113.00

Estimated to ship on12 May 2025

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5 MG
$113.00
25 MG
$363.00

About This Item

Empirical Formula (Hill Notation):
C18H14N2O3
CAS Number:
1099592-35-4
Molecular Weight:
306.32
MDL number:
MFCD00196698
UNSPSC Code:
12352200
NACRES:
NA.77

$113.00

Estimated to ship on12 May 2025

Request a Bulk Order

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

OC1=CC=CC=C1C(N/N=C/C2=C(C=CC=C3)C3=CC=C2O)=O

InChI

1S/C18H14N2O3/c21-16-8-4-3-7-14(16)18(23)20-19-11-15-13-6-2-1-5-12(13)9-10-17(15)22/h1-11,21-22H,(H,20,23)/b19-11+

InChI key

ZZSJOLDICPVVAV-YBFXNURJSA-N

Biochem/physiol Actions

NSAH is a cell penetrant, potent and selective nonnucleoside reversible inhibitor of large subunit (hRRM1) of hRR (human ribonucleotide reductase). NSAH binds to catalytic site of hRRM1. It inhibits hRR in cells. NSAH exhibit potent cytotoxicity toward cancer cells, while demonstrated very moderate toxicity against normal blood progenitor cells.
cell penetrant, potent and selective nonnucleoside reversible inhibitor of large subunit (hRRM1) of hRR (human ribonucleotide reductase)

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Md Faiz Ahmad et al.
Proceedings of the National Academy of Sciences of the United States of America, 114(31), 8241-8246 (2017-07-19)
Human ribonucleotide reductase (hRR) is crucial for DNA replication and maintenance of a balanced dNTP pool, and is an established cancer target. Nucleoside analogs such as gemcitabine diphosphate and clofarabine nucleotides target the large subunit (hRRM1) of hRR. These drugs

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