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SML2406

Sigma-Aldrich

JI130

≥95% (HPLC)

Synonym(s):

(E)-N-(2-(Allyloxy)phenethyl)-3-(7-methoxy-1H-indol-3-yl)acrylamide

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5 MG
$94.40
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$411.00

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5 MG
$94.40
25 MG
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About This Item

Empirical Formula (Hill Notation):
C23H24N2O3
CAS Number:
2234271-86-2
Molecular Weight:
376.45
UNSPSC Code:
12352200
NACRES:
NA.77

$94.40

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Assay

≥95% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C(/C=C/C1=CNC2=C1C=CC=C2OC)NCCC3=CC=CC=C3OCC=C

InChI

1S/C23H24N2O3/c1-3-15-28-20-9-5-4-7-17(20)13-14-24-22(26)12-11-18-16-25-23-19(18)8-6-10-21(23)27-2/h3-12,16,25H,1,13-15H2,2H3,(H,24,26)/b12-11+

InChI key

BNTYDBBGNPFECO-VAWYXSNFSA-N

Biochem/physiol Actions

JI130 is a cell penetrant, potent and selective inhibitor of the helix-loop-helix transcription factor Hes1 that blocks Hes1-mediated transcriptional repression. JI130 potently inhibits pancreatic cancer cell lines proliferation, and shrink tumor in a mice pancreatic tumor xenograft model.
cell penetrant, potent and selective inhibitor of the helix-loop-helix transcription factor Hes1 that blocks Hes1-mediated transcriptional repression

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Amelie Perron et al.
The Journal of biological chemistry, 293(21), 8285-8294 (2018-03-11)
The transcription factor Hes family basic helix-loop-helix transcription factor 1 (Hes1) is a downstream effector of Notch signaling and plays a crucial role in orchestrating developmental processes during the embryonic stage. However, its aberrant signaling in adulthood is linked to

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