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SML1968

Sigma-Aldrich

Phentermine hydrochloride

≥98% (HPLC)

Synonym(s):

α,α-Dimethylphenethylamine hydrochloride, α-Benzylisopropylamine hydrochloride, 1,1-Dimethyl-2-phenylethylamine hydrochloride, 2-Methyl-1-phenylpropan-2-amine hydrochloride, 2-Phenyl-tert-butylamine hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C10H15N · HCl
CAS Number:
1197-21-3
Molecular Weight:
185.69
EC Number:
214-821-9
MDL number:
MFCD00058289
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

H2O: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

Cl.CC(C)(N)Cc1ccccc1

InChI

1S/C10H15N.ClH/c1-10(2,11)8-9-6-4-3-5-7-9;/h3-7H,8,11H2,1-2H3;1H

InChI key

NCAIGTHBQTXTLR-UHFFFAOYSA-N

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Biochem/physiol Actions

Phentermine is a sympathomimetic that releases norepinephrine and epinephrine in CNS and periphery reducing hunger. Similarly to other amphetamines, phentermine potently inhibits DA and 5-HT uptake.

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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The dopamine transporter (DAT) is the primary site of action for psychostimulant drugs such as cocaine, methylphenidate, and amphetamine. Our previous work demonstrated a reduced ability of cocaine to inhibit the DAT following high-dose cocaine self-administration (SA), corresponding to a
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Journal of neurophysiology, 114(1), 585-607 (2015-05-15)
Obesity is a worldwide health problem that has reached epidemic proportions. To ameliorate this problem, one approach is the use of appetite suppressants. These compounds are frequently amphetamine congeners such as diethylpropion (DEP), phentermine (PHEN), and bupropion (BUP), whose effects

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