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SML0627

Sigma-Aldrich

ML-SA1

≥95% (HPLC), powder, TRPML channel agonist

Synonym(s):

1-[(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)acetyl]-1,2,3,4-tetrahydro-2,2,4-trimethyl-quinoline, 2-(2-Oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl)ethyl)isoindoline-1,3-dione, Mucolipin Synthetic Agonist 1

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About This Item

Empirical Formula (Hill Notation):
C22H22N2O3
CAS Number:
332382-54-4
Molecular Weight:
362.42
UNSPSC Code:
12352200
NACRES:
NA.77

product name

ML-SA1, ≥95% (HPLC)

Assay

≥95% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL, clear (warmed)

storage temp.

2-8°C

InChI

1S/C22H22N2O3/c1-14-12-22(2,3)24(18-11-7-6-8-15(14)18)19(25)13-23-20(26)16-9-4-5-10-17(16)21(23)27/h4-11,14H,12-13H2,1-3H3

InChI key

KDDHBJICVBONAX-UHFFFAOYSA-N

Application

ML-SA1 has been used as a transient receptor potential cation channel mucolipin 1 (TRPML1/ML1) agonist.

Biochem/physiol Actions

ML-SA1 is a potent and selective cell permeable agonist of lysosomal mucolipin transient receptor potential channels (TRPML) 1, 2, 3 that significantly increases [Ca2+]cyt in HEK293 cells stably- or transiently-expressing mutant TRPML1 channels ML1-4A.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Gastric acid secretion from parietal cells is mediated by a Ca2+ efflux channel in the tubulovesicle.
Sahoo N, et al.
Developmental Cell, 41(3), 262-273 (2017)
Hongyan Yu et al.
British journal of cancer, 125(10), 1420-1431 (2021-09-23)
Prostate cancer (Pca) is the most common cancer type among males worldwide. Dysregulation of Ca2+ signaling plays important roles during Pca progression. However, there is lack of information about the role of endolysosomal Ca2+ -permeable channels in Pca progression. The
Dengqin Zhong et al.
Nature communications, 14(1), 3997-3997 (2023-07-07)
Uranium (U) is a well-known nephrotoxicant which forms precipitates in the lysosomes of renal proximal tubular epithelial cells (PTECs) after U-exposure at a cytotoxic dose. However, the roles of lysosomes in U decorporation and detoxification remain to be elucidated. Mucolipin
Simona Ida Scorza et al.
International journal of molecular sciences, 24(2) (2023-01-22)
Lysosomes are acidic Ca2+ storage organelles that actively generate local Ca2+ signaling events to regulate a plethora of cell functions. Here, we characterized lysosomal Ca2+ signals in mouse renal collecting duct (CD) cells and we assessed their putative role in
Lalit Pukhrambam Singh et al.
Diseases (Basel, Switzerland), 9(4) (2021-12-24)
Chronic hyperglycemia-induced thioredoxin-interacting protein (TXNIP) expression, associated oxidative/nitrosative stress (ROS/RNS), and mitochondrial dysfunction play critical roles in the etiology of diabetic retinopathy (DR). However, there is no effective drug treatment to prevent or slow down the progression of DR. The
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