SAB4500736

Anti-4E-BP1 antibody produced in rabbit

affinity isolated antibody

• Synonym(s): 4EBP1, EIF4EBP1, Eukaryotic translation initiation factor 4E binding protein 1, Insulin-stimulated EIF-4E binding protein PHAS-I, P/OKCL.6
• MDL number: MFCD04040379
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen 12 kDa
• species reactivity: rat, mouse, human
• concentration: ~1 mg/mL
• technique(s): ELISA: 1:5000; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000
• NCBI accession no.: Q13541
• UniProt accession no.: Q13541
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... EIF4EBP1(1978)

Description

General description

Anti-4E-BP1 Antibody detects endogenous levels of total 4E-BP1 protein.

The gene E1F4EBP1 (eukaryotic translation initiation factor 4E binding protein 1) is located on human chromosome 8p11. 4E-BP1 is a multifactor regulated multifunctional protein. It belongs to the translation repressor protein family.

Immunogen

The antiserum was produced against synthesized peptide derived from human 4E-BP1.

Immunogen Range: 30-79

Application

Anti-4E-BP1 antibody has been used in western blotting.

Biochem/physiol Actions

E1F4EBP1 (eukaryotic translation initiation factor 4E binding protein 1) is involved in protein synthesis, cell growth and survival. Phosphorylation of E1F4EBP1 releases it from eIF4E (eukaryotic translation initiation factor 4E), thereby resulting in cap-dependent translation. E1F4EBP1 is also involved in tumorigenesis and the gene is overexpressed in various carcinomas. It also serves as a substrate for mTORC1 (mammalian target of rapamycin complex 1).

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: nwg
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable