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Key Documents

SAB4500579

Sigma-Aldrich

Anti-Cytochrome P450 1A1 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

AHH, AHRR, CP11, CYP1, CYPIA1

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About This Item

MDL number:
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 58 kDa

species reactivity

rat, mouse, human

concentration

~1 mg/mL

technique(s)

ELISA: 1:20000
western blot: 1:500-1:1000

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... CYP1A1(1543)

General description

Anti-Cytochrome P450 1A1 Antibody detects endogenous levels of total Cytochrome P450 1A1 protein.
The cytochrome P450 family 1 subfamily A member 1 (CYP1A1) gene with seven exons, is mapped to human chromosome 15q24.1. The encoded protein is primarily expressed in extrahepatic tissues.[1]

Immunogen

The antiserum was produced against synthesized peptide derived from human Cytochrome P450 1A1/2.

Immunogen Range: 71-120

Biochem/physiol Actions

Cytochrome P450 family 1 subfamily A member 1 (CYP1A1) catalyzes 2-OH hydroxylation in the endometrium.[1] In addition, it also catalyzes the oxidation of various structurally unrelated compounds, such as steroids and fatty acids.[2] CYP family members play an important role in metabolic activation and detoxification of tobacco-derived carcinogen and other xenobiotics. CYP1A1 also facilitates drug metabolism.[3] Mutation in the gene increases the risk of susceptibility to colorectal cancer and acute lymphoblastic leukemia (ALL).[4][5]

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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CYP1A1 Ile462Val polymorphism contributes to colorectal cancer risk: A meta-analysis
Jin JQ, et al.
World Journal of Gastroenterology, 17(2), 260-260 (2011)
Allele and genotype frequencies of the polymorphic cytochrome P450 genes (CYP1A1, CYP3A4, CYP3A5, CYP2C9 and CYP2C19) in the Jordanian population.
Yousef AM, et al.
Molecular Biology Reports, 39(10), 9423-9433 (2012)
CYP1A1, SULT1A1, and SULT1E1 polymorphisms are risk factors for endometrial cancer susceptibility.
Hirata H, et al.
Cancer, 112(9), 1964-1973 (2008)
Genetic polymorphisms of NQO1, CYP1A1 and TPMT and susceptibility to acute lymphoblastic leukemia in a Tunisian population.
Ouerhani S, et al.
Molecular Biology Reports, 40(2), 1307-1314 (2013)
An additional case of the recurrent 15q24. 1 microdeletion syndrome and review of the literature.
Ng I S, et al.
Twin Research and Human Genetics : The Official Journal of the International Society for Twin Studies, 14(4), 333-339 (2011)

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