R107
Ro 41-1049 hydrochloride
solid
Synonym(s):
N-(2-Aminoethyl)-5-(3-fluorophenyl)-4-thiazolecarboxamide hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C12H12FN3OS · HCl
CAS Number:
Molecular Weight:
301.77
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
form
solid
color
white
solubility
H2O: soluble
SMILES string
Cl[H].NCCNC(=O)c1ncsc1-c2cccc(F)c2
Gene Information
human ... MAOA(4128)
Biochem/physiol Actions
Selective, reversible, orally-active MAO-A inhibitor.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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M J Heeringa et al.
Journal of neural transmission (Vienna, Austria : 1996), 104(6-7), 593-603 (1997-01-01)
The effect of enzyme-inhibiting adjuvants on L-DOPA + benserazide-induced contralateral turning in unilateral 6-hydroxydopamine (6-OHDA)-lesioned rats was studied. Both the number of turns and the duration of turning were examined. Inhibition of MAO-A with 10 mg/kg Ro 41-1049 increased both
A Ozaita et al.
British journal of pharmacology, 121(5), 901-912 (1997-07-01)
1. I2-Imidazoline sites ([3H]-idazoxan binding) have been identified on monoamine oxidase (MAO) and proposed to modulate the activity of the enzyme through an allosteric inhibitory mechanism (Tesson et al., 1995). The main aim of this study was to assess the
M H Fernandes et al.
The Journal of pharmacology and experimental therapeutics, 255(3), 1309-1313 (1990-12-01)
The present study has examined the effects of two selective inhibitors of monoamine oxidase (MAO) type A and B, respectively Ro 41-1049 and Ro 19-6327, on the deamination of newly synthesized dopamine (DA) in kidney slices incubated with exogenous L-3,4-dihydroxyphenylalanine
J Saura et al.
Life sciences, 59(16), 1341-1349 (1996-01-01)
Localization of monoamine oxidases (MAO) A and B and beta-adrenoceptors, was studied in aged human peripheral tissues (age 68-80 years) by quantitative autoradiography. The tissues analyzed were heart, lung, liver, kidney, spleen and duodenum. [3H]Ro41-1049 and [3H]lazabemide, two recently characterized
J Saura et al.
Neurobiology of aging, 18(5), 497-507 (1997-12-09)
Variations of monoamine oxidases (MAO) A and B were studied during aging in 27 human subjects (age range 17-93 years) in 18 brain structures of temporal cortex, frontal gyrus, hippocampal formation, striatum, cerebellum, and brainstem. [3H]Ro41-1049 and [3H]lazabemide were used
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