P6462
Protein Tyrosine Phosphatase Substrate Monophosphate
≥97% (HPLC)
Synonym(s):
[pTyr1146]-Insulin Receptor fragment 1142-1153, PTPase Substrate Phosphate
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About This Item
Empirical Formula (Hill Notation):
C72H108N19O27P
CAS Number:
Molecular Weight:
1702.71
MDL number:
UNSPSC Code:
12352202
NACRES:
NA.84
Assay
≥97% (HPLC)
form
powder
storage temp.
−20°C
Amino Acid Sequence
Thr-Arg-Asp-Ile-Tyr[PO3H2]-Glu-Thr-Asp-Tyr-Tyr-Arg-Lys
Other Notes
Lyophilized from 0.1% TFA in H2O
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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L Stadtmauer et al.
The Journal of biological chemistry, 261(21), 10000-10005 (1986-07-25)
Three peptides were synthesized corresponding to potential autophosphorylation sites of the beta subunit of the human insulin receptor. These were peptide 1150 corresponding to amino acids 1142-1153 of the pro-receptor, peptide 960 corresponding to amino acids 952-961 of the proreceptor
T O'Hare et al.
The Journal of biological chemistry, 264(1), 602-610 (1989-01-05)
We are interested in developing methods to rigorously characterize the intrinsic enzymatic activity of the insulin receptor. We have previously shown that the intact, kinase active form of the receptor can be separated from inactive forms isolated from human placenta.
M J King et al.
FEBS letters, 237(1-2), 137-140 (1988-09-12)
Synthetic peptide 1142-1153 of the insulin receptor was phosphorylated on tyrosine by the insulin receptor and found to be a potent substrate for dephosphorylation by rat liver particulate and soluble phosphotyrosyl protein phosphatases. Apparent Km values were approximately 5 microM.
Bannwarth, W., and Kitas, E.A.
Helvetica Chimica Acta, 75, 707-707 (1992)
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