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M3404

Sigma-Aldrich

(±)-p-Methoxyamphetamine hydrochloride

Synonym(s):

PMA hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C10H15NO · HCl
CAS Number:
52740-56-4
Molecular Weight:
201.69
MDL number:
MFCD00051431
UNSPSC Code:
12352200
PubChem Substance ID:
24896840

drug control

USDEA Schedule I; Home Office Schedule 1; stupéfiant (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
veterinary

SMILES string

Cl.COc1ccc(CC(C)N)cc1

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Biochem/physiol Actions

CNS stimulant and hallucinogen; more potent transport inhibitor and releaser of serotonin than of dopamine.

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H301

Precautionary Statements

P301 + P310

Hazard Classifications

Acute Tox. 3 Oral

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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K M Hegadoren et al.
Journal of psychiatry & neuroscience : JPN, 19(1), 57-62 (1994-01-01)
Experiments were conducted to compare the effects of 4-ethoxyamphetamine, a novel "designer" amphetamine, with (+)-amphetamine and an earlier "designer" amphetamine, 4-methoxyamphetamine, on rats. (+)-Amphetamine significantly decreased frequency threshold measures in an intracranial self-stimulation (ICSS) procedure using medial forebrain bundle electrodes
D Wu et al.
Biochemical pharmacology, 53(11), 1605-1612 (1997-06-01)
The interaction of fifteen amphetamine analogs with the genetically polymorphic enzyme CYP2D6 was examined. All fourteen phenylisopropylamines tested were competitive inhibitors of CYP2D6 in human liver microsomes. The presence of a methylenedioxy group in the 3,4-positions of both amphetamine (Ki
Keiko Kudo et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 855(1), 115-120 (2007-04-04)
Metamphetamine (MA) is one of the most frequently encountered abused drugs in Japan and the Triage immunoassay kit is often used to screen for this drug. However, immunoassay screening also gives positive results with other structurally related compounds, such as
Antonio Doménech et al.
The Analyst, 135(6), 1449-1455 (2010-04-22)
Electrochemical discrimination between dopamine and psychotropic drugs which have in common a skeletal structure of phenethylamine, can be obtained using acyclic receptors L(1) and L(2), containing two terminal 3-alkoxy-5-nitroindazole rings. Upon attachment to graphite electrodes, L(1) and L(2) exhibit a
Emily J Jaehne et al.
Pharmacology, biochemistry, and behavior, 81(3), 485-496 (2005-05-21)
3,4-Methylenedioxymethamphetamine (MDMA, 'ecstasy') and related amphetamines such as para-methoxyamphetamine (PMA) disrupt normal thermoregulation in humans and rats. Behavior, an important component of thermoregulation in mammals, has not been investigated with respect to these drugs. This is surprising as harm minimization
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