I7904

Indomethacin heptyl ester

methyl acetate solution, ≥98% (HPLC)

• Empirical Formula (Hill Notation): C₂₆H₃₀ClNO₄
• CAS Number: 282728-47-6
• Molecular Weight: 455.97
• EC Number: 201-185-2
• MDL number: MFCD03412025
• UNSPSC Code: 12352200
• PubChem Substance ID: 329815317

Properties

• Assay: ≥98% (HPLC)
• form: methyl acetate solution
• potency: 0.04 μM IC₅₀ (for human recombinat COX-2)
• shipped in: wet ice
• storage temp.: −20°C
• SMILES string: CCCCCCCOC(=O)Cc1c(C)n(C(=O)c2ccc(Cl)cc2)c3ccc(OC)cc13
• InChI: 1S/C26H30ClNO4/c1-4-5-6-7-8-15-32-25(29)17-22-18(2)28(24-14-13-21(31-3)16-23(22)24)26(30)19-9-11-20(27)12-10-19/h9-14,16H,4-8,15,17H2,1-3H3
• InChI key: PYBCHCVNKGZCOH-UHFFFAOYSA-N

Description

Application

Used to inhibit COX-1 and COX-2. To achieve 50% inhibition of human recombinant COX-2 use I7904 at 0.04 uM/mL .

Biochem/physiol Actions

Potent cyclooxygenase-2 inhibitor. 1700 times greater activity against COX-2 than COX-1.

Other Notes

Derivatized indomethacin.

Safety Information

• Pictograms: GHS02,GHS07
• Signal Word: Danger
• Hazard Statements: H225,H319,H336
• Precautionary Statements: P210 - P233 - P240 - P241 - P242 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3
• Target Organs: Central nervous system
• Supplementary Hazards: EUH066
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 3
• Flash Point(F): 8.6 °F - closed cup
• Flash Point(C): -13 °C - closed cup